PEGylated Protein Drugs: Basic Science and Clinical Applications

Name: PEGylated Protein Drugs: Basic Science and Clinical Applications
Brand: Springer Nature
SKU: 9783764386788
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Springer Nature

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9783764386788

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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

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