Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Immunological Synapse

Immunological Synapse

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783642038570
Condition
New
Product Description

The proper physiological functioning of most eukaryotic cells requires their assembly into multi-cellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptideMHC antigens initiates T cell activation, adhesion, and immune-effectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole- lar basis of antigen-receptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par- cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCRrecognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by self-peptideMHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response.

Available Colors
Available Sizes
1 Offer Price Range: $169.99 - $169.99
BEST PRICE

Single Product Purchase

$169.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$169.99 $169.99

$169.99
See Site In stock Visit Store

Similar Products

Touristikmanagement 2

$39.99

Automata, Languages, and Programming

$54.99

Fertigungsverfahren der Mechatronik, Feinwerk- und Przisionsgertetechnik

$39.99

The Future of Service Post-COVID-19 Pandemic, Volume 2

$84.99

Decision Processes by Using Bivariate Normal Quantile Pairs

$109.99

Einfhrung in die Strukturdynamik

$29.99

Lsungen und Adsorption

$74.99

Postdigital Learning Spaces

$179.99

Second-Generation High-Temperature Superconducting Coils and Their Applications for Energy Storage

$109.99

Memory and Punishment

$139.99

Medienmoderne

$29.99

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

$199.99

The Anglo-American Paper War

$39.99

Migmatites

$39.99

What Is a Friend?

$3.71

Marketingtechnologien

$59.99

Attitudes, Aspirations and Welfare

$119.99

Fish Tank Friends: Do I Have to Go to the Party? (Hardcover)

$13.49

Mia Mayhem: Mia Mayhem vs. the Super Bully

$5.21

Counter-Terrorism Policing

$84.99

C. Wright Mills and the Ending of Violence

$54.99

Wie Organisationen erfolgreich agil werden

$17.99

We're Going on a Treasure Hunt

$4.46

Sometimes I'm Bombaloo

$5.99

Voltage-Sensitive Ion Channels

$169.00

Finanzierungstheorie

$19.99

mir: Management International Review

$39.99

Eurasian Economic Perspectives

$169.99

Barakah Beats (Hardcover)

$13.49

Plant Synthetic Biology

$109.00

Lehrbuch der Herzkrankheiten

$49.99

Astrobiology and Cuatro Cinegas Basin as an Analog of Early Earth

$109.99

Language Learning with Technology

$139.99

Soft Computing Applications

$109.99

Stdtebau und Schnellverkehr

$49.99

Grundlagen und Praxis Chemischer Tumorbehandlung

$59.99

Das Geheimnis erfolgreicher Personalbeschaffung

$64.99

Spherical Crystallization as a New Platform for Particle Design Engineering

$199.99

Identifikation dynamischer Systeme

$64.99

Fractal Geometry and Stochastics

$84.99