Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Clinical Applications of Immunotoxins

Clinical Applications of Immunotoxins

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783642721557
Condition
New
Product Description

1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are among the most toxic substances known. However, because they bind to cell surface receptors that are present on most normal cells, unmodified toxins are generally useless as anti-cancer agents. To convert toxins into more selective agents, their binding domains are either eliminated or disabled and replaceq with cell binding antibodies that are tumor-selective.

Available Colors
Available Sizes
1 Offer Price Range: $84.99 - $84.99
BEST PRICE

Single Product Purchase

$84.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$84.99 $84.99

$84.99
See Site In stock Visit Store

Similar Products

Environmental Physiology of Fishes

$329.99

Deckungsbeitragsrechnung fr Krankenhuser

$59.99

Gestalttheorie und Psychotherapie

$59.99

Supply Chain Finance

$129.99

How the SELF Controls Its BRAIN

$79.99

Trusted Computing

$54.99

Grundlagen der automatisierten Datenverarbeitung

$69.99

The Phenomenology of a Performative Knowledge System

$89.99

Vibration, Acoustics and Strain Measurement

$109.99

Modern Problems of Molecular Physics

$169.00

Smart Urban Mobility

$159.99

Gruppen mit krperlich Kranken

$69.99

Selected Exercises in Galactic Astronomy

$39.99

Emerging Trends and Applications in Artificial Intelligence

$219.99

Grundlagen und Anwendung der Steuerungstechnik

$59.99

Zentralstaubsauger fr Einfamilienhuser und Wohnungen

$17.99

Microbial Processes and Products

$129.00

Technologie der Textilfasern

$59.99

Poetry for Young People: Langston Hughes

$5.21

Sanierung in der Insolvenz

$79.99

Systemanalyse kompakt

$19.95

Handbook on Knowledge Management 2

$219.99

Multihazard Simulation and Cyberinfrastructure

$54.99

Causal Analytics for Applied Risk Analysis

$329.99

The Open Incubator Model

$54.99

Lectures on the Theory of Algebraic Numbers

$79.99

Greatness and Philosophy

$54.99

Entropy, Deviations, and Statistical Mechanics

$44.99

Studies to Combat COVID-19 using Science and Engineering

$179.99

Polizei als lernende Organisation

$69.99

NATO and the Quest for Post-Cold War Security

$109.99

Sociopolitical Ecology

$109.99

Essays on Mathematical Robotics

$109.99

Jordan: A Study in Political Development (19211965)

$39.99

What is Global Engineering Education For? The Making of International Educators, Part III

$44.99

The Structure of Digital Partner Choice

$54.99

The Rivers of Florida

$84.99

Pituitary Tumors

$79.99

Marginalisierung, Stadt und Soziale Arbeit

$49.99

Sicherheitsfibel

$69.99