Uptake and Trafficking of Protein Toxins

Name: Uptake and Trafficking of Protein Toxins
Brand: Springer Nature
SKU: 9783319588933
Availability: InStock

Uptake and Trafficking of Protein Toxins

Brand

Springer Nature

Manufacturer

N/A

Part Number

GTIN

9783319588933

Condition

New

0 Reviews

0 Questions | 0 Answers

Product Description

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The books closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins translocation channels. This volume offers an up-to-date resource for scientists.

Available Colors

N/A

Available Sizes

N/A

1 Offer Price Range: $139.00 - $139.00

BEST PRICE

Single Product Purchase

$125.10

@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller	Contact Seller	List Price	On Sale	Shipping	Best Promo	Final Price	Volume Discount	Financing	Availability	Seller's Page
BEST PRICE 1 Product Purchase @ Link.springer.com Rate Seller This functionality is for registered users only. Go to Login/Register		$139.00	$139.00		10% OFF This deals requires coupon Get Code Here your10off @ Link.springer.com Deals Ends 31/08/2025	$125.10		See Site	In stock	Visit Store