Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Alternate Programmed Cell Death Signaling in Antiviral Host Defense

Alternate Programmed Cell Death Signaling in Antiviral Host Defense

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783031452772
Condition
New
Product Description

This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV)where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.

Available Colors
Available Sizes
1 Offer Price Range: $119.00 - $119.00
BEST PRICE

Single Product Purchase

$119.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$119.00 $119.00

$119.00
See Site In stock Visit Store

Similar Products

Thrombopoiesis and Thrombopoietins

$89.00

Civil Wars and Third-Party Interventions in Africa

$109.99

Marketing fr Unternehmensberatung

$49.99

Smart Sensors Measurements and Instrumentation

$219.99

Kompetenzmanagement in der Praxis

$79.99

ICT Innovations 2019. Big Data Processing and Mining

$39.99

Auxiliary Signal Design in Fault Detection and Diagnosis

$39.99

Communists on Education and Culture, 1848-1948

$54.99

Advances in Computing and Data Sciences

$54.99

Genetic Engineering of Microorganisms for Chemicals

$109.99

Disorders of Articulation

$39.99

Computational Biomechanics for Medicine

$169.99

Cohesive Properties of Semiconductors under Laser Irradiation

$39.99

Boa Constructor: A Branches Book (The Binder of Doom #2)

$5.24

Colonial Migrants and Racism

$84.99

Analysis and Strategies for Sustainable Regional Planning

$84.99

Soft Tissue Pathology for Clinicians

$39.99

Fabel

$19.99

Einfhrung in Grundbegriffe und Grundfragen der Erziehungswissenschaft

$37.99

Skandinavische Literaturgeschichte

$49.99

Statistical Mechanics and Field Theory: Mathematical Aspects

$84.99

Brain-Computer Interface Research

$54.99

Case Studies in Bayesian Statistics, Volume II

$109.99

Teaching Living Legends

$54.99

Rapid Urbanisation, Urban Food Deserts and Food Security in Africa

$99.99

Das probabilistische SIR-Modell (PSIR) im Pandemieprozess

$17.99

Berichte zu Pflanzenschutzmitteln 2010

$27.99

Electrical Power System Protection

$449.99

Owl Monkeys

$149.00

Fundamental Structural Aspects and Features in the Bioengineering of the Gas Exchangers: Comparative

$109.99

The Rademacher System in Function Spaces

$169.99

Handbuch Ontologie

$119.99

Combinatorics, Graph Theory and Computing

$199.99

Advances in Bioprocess Technology

$169.99

Inventory Control Models with Motivational Policies

$109.99

Web-basierte Anwendungen Virtueller Techniken

$89.99

UbiComp 2003: Ubiquitous Computing

$54.99

Innovative Approaches to the On-Site Assessment and Remediation of Contaminated Sites

$169.99

Climate Change and Global Development

$109.00

Creative Simulations

$169.99