Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

RUNX Proteins in Development and Cancer

RUNX Proteins in Development and Cancer

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9789811032318
Condition
New
Product Description

This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both gatekeepers that modulate p53 responses and caretakers that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.

Available Colors
Available Sizes
1 Offer Price Range: $169.00 - $169.00
BEST PRICE

Single Product Purchase

$169.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$169.00 $169.00

$169.00
See Site In stock Visit Store

Similar Products

Fruit Processing: Nutrition, Products, and Quality Management

$169.99

Software Technologies for Embedded and Ubiquitous Systems

$39.99

Grand Societal Challenges in Information Systems Research and Education

$54.99

Applications and Techniques in Information Security

$54.99

Bewusstseinsvorgang und Gehirnprozess

$59.99

Fallstudien zum Strategischen Management

$49.99

Gestaltung und Bewertung von Genuscheinkapital

$59.99

Der westdeutsche Konsumgterexport nach dem zweiten Weltkrieg

$59.99

Evaluating the Language of Argument

$79.99

Divided Gulf

$109.00

MAP Kinases in Plant Signal Transduction

$84.99

Mustafa Barzani and the Kurdish Liberation Movement

$169.99

Die Beeinflussung diazotierter, nicht gekuppelter Frbungen durch Leuchtstofflampen whrend des Frb

$59.99

I Can Read! Level 1 - Splat the Cat: Up in the Air at the Fair

$3.71

Studies on Men's Health and Fertility

$219.99

Soft Computing in Communications

$169.99

Forensic Toxicology

$39.99

Network Programming with Go

$54.99

Inverse Problems in Groundwater Modeling

$249.99

Automatic Speech and Speaker Recognition

$219.99

Ergebnisse der Allgemeinen Pathologie und Pathologischen Anatomie des Menschen und der Tiere

$59.99

Ras Activity and Signaling

$109.00

The Economics of Professional Road Cycling

$159.99

Lipid-mediated Protein Signaling

$169.99

Windkrfte an ebenen und gewlbten Platten

$59.99

Polychlorinated Dibenzo-p-dioxins and -furans (PCDDs/PCDFs): Sources and Environmental Impact, Epide

$54.99

Poetry of Attention in the Eighteenth Century

$54.99

No Fixed Abode

$84.99

Current Topics in Soil Science

$179.99

VLADIMIR I. ARNOLDCollected Works

$169.99

Citizens at the Gates

$19.99

Laparoscopic Surgery

$169.99

Space Debris and Other Threats from Outer Space

$54.99

Current Concepts of Diagnosis and Treatment of Bone and Soft Tissue Tumors

$84.99

Alltagserfahrungen von Jugendlichen aus Soldatenfamilien der Bundeswehr

$59.99

Hirnpotentiale

$19.99

Die Bedeutung der Volition fr den Studienerfolg

$49.99

Telecommunication Markets

$169.99

Kpfmller Theoretische Elektrotechnik

$129.99

Surveillance Schools

$39.99