Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

The mRNA Metabolism in Human Disease

The mRNA Metabolism in Human Disease

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030199654
Condition
New
Product Description

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. The precursor mRNA is transcribed from DNA, processed by removal of introns and addition of the cap structure and the poly(A) tail. The mature mRNA is then exported to the cytoplasm where it is translated into protein and finally degraded. In this process, mRNA is associated with RNA-binding proteins forming ribonucleoprotein complexes, whose protein content evolves throughout the lifetime of the mRNA. While the complexity of eukaryotic gene expression allows the production of proteins to be controlled at many levels, it also makes the process vulnerable to errors. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism. This condition plays a fundamental role in the pathogenesis of several disease processes, such as neurodegeneration and oncogenesis. Besides, exciting recent data have shown that cellular RNAs can be modified post-transcriptionally via dynamic and reversible chemical modifications, the so-called epitranscriptome. These modifications can alter mRNA structure, being able to modulate different steps of the mRNA metabolism that can be associated with various human diseases, such as systemic lupus erythematosus and cancer. This book provides a collection of novel studies and hypotheses aimed to define the pathophysiological consequences of altered mRNA metabolism events in human cells, and is written for a wide spectrum of readers in the field of gene expression regulation. The last chapter highlights how the discovery of disease-causing defects (or modifications) in mRNA can provide a variety of therapeutic targets that can be used for the development of new RNA-based therapeutics. Hopefully, it may also contribute to inspire the drug-developing scientific community.

Available Colors
Available Sizes
1 Offer Price Range: $119.00 - $119.00
BEST PRICE

Single Product Purchase

$119.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$119.00 $119.00

$119.00
See Site In stock Visit Store

Similar Products

Flex Solutions

$54.99

Static and Dynamic Coupled Fields in Bodies with Piezoeffects or Polarization Gradient

$169.99

Spectral Analysis

$49.95

Zerbricht die Wirklichkeit ?

$79.99

The Difficult Flowering of Surinam

$54.99

Adaptable Embedded Systems

$109.99

Human Brainwaves

$29.99

Technology Implementation in Second Language Teaching and Translation Studies

$109.99

Leptospira spp

$89.00

Schulinspektion als Steuerungsimpuls?

$49.99

Investment-Banking-Strategien deutscher Banken

$99.99

Organizational Acceptance of Artificial Intelligence

$54.99

Landscape of 21st Century Mathematics

$79.99

Fighting Terror Online

$54.99

Flexural Testing of Weld Site and HVOF Coating Characteristics

$54.99

Tax Insight

$37.99

Law Enforcement, Leadership and Wellbeing

$44.99

Naturschutz in Bergbaufolgelandschaften

$59.99

Hobbesian Internationalism

$59.99

Solar Cookers in the Third World

$59.99

Der Sugling

$59.99

Writing Under the Influence

$19.99

Aktionrsorientierung der Unternehmenspolitik?

$59.99

Exploring Game Mechanics

$37.99

Klinische Neurologie

$64.99

Production of Platform Chemicals from Sustainable Resources

$149.00

Sozialforschung im Internet

$44.99

Education in the Era of Globalization

$84.99

Formeln und Aufgaben zur Technischen Mechanik 2

$14.99

Self-Sustaining Systems

$39.99

SDN and NFV Security

$119.99

Wireless Sensor Networks and Applications

$169.99

Geldanlage und Steuer 2018

$44.99

Critical Factors for Adoption of Customer Relationship Management

$39.99

Going Public in bergangskonomien

$59.99

DNA Information: Laws of Perception

$54.99

Guidance on the Classification of Offshore Containers

$22.99

The Physics and Physical Chemistry of Water

$84.99

Nutrient-Induced Responses in Eukaryotic Cells

$169.99

Immunotherapy of Melanoma

$219.99