Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030506216
Condition
New
Product Description

Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel druggable lipid signaling targets.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

The State Visits of Edward VII

$99.00

Ergebnisse der Inneren Medizin und Kinderheilkunde

$59.99

Das Zwillingsparadoxon unter Bercksichtigung der Gravitation

$17.99

Language Revitalisation and Social Transformation

$169.99

Advances in Intelligent Healthcare Delivery and Management

$169.00

Sades Philosophical System in its Enlightenment Context

$89.99

Measuring and Managing Operational Risk

$44.99

Strmungsmechanik

$29.99

The Discourse Trap and the US Military

$54.99

Modal Analysis of Nonlinear Mechanical Systems

$84.99

Popular Media and Animals

$99.00

Gallium Arsenide Digital Circuits

$169.99

Jahresbericht der forstlich-phnologischen Stationen Deutschlands

$59.99

Lehrbuch der Theoretischen Physik

$24.99

Johnson on Language

$109.99

International Yearbook of Soil Law and Policy 2022

$59.99

Medical Image Computing and Computer Assisted Intervention MICCAI 2021

$139.99

Excitonic and Photonic Processes in Materials

$109.99

Ethiopian Yearbook of International Law 2018

$84.99

Die Theorie der Gewichtsstaumauern unter Rcksicht auf die neueren Ergebnisse der Festigkeitslehre

$59.99

Einfhrung in die politischen Theorien der Gegenwart

$29.99

Pathways to Peace

$37.99

The Art of Teaching Physics with Ancient Chinese Science and Technology

$64.99

Cryptography and Coding

$54.99

COMAL in Beispielen

$69.99

The Turning Points of the New Phenomenological Era

$169.00

Exergy for A Better Environment and Improved Sustainability 1

$329.99

Inverse Problems and Related Topics

$169.99

Adaptive Modelle fr die Kraftfahrzeugdynamik

$149.00

YOUMARES 9 - The Oceans: Our Research, Our Future

$54.99

Data and Applications Security and Privacy XXXIII

$108.00

Principles of Molecular Oncology

$219.99

Normative Power Europe

$109.99

Konzeption und Einfhrung eines Qualittsmanagementsystems

$59.99

Ratschlge zum mathematischen Umgang mit Ungewiheit

$49.99

Variational Principles of Continuum Mechanics

$109.00

Darwin2K

$109.99

Die deutsch Finanzkraft

$54.99

Recent Developments in Infinite-Dimensional Analysis and Quantum Probability

$84.99

H-Optimal Control and Related Minimax Design Problems

$89.99