Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Pharmacology of the WNT Signaling System

Pharmacology of the WNT Signaling System

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030854980
Condition
New
Product Description

This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Versuch ber den deutschen Gegenwartsroman

$29.99

Metal and Metal Oxides for Energy and Electronics

$139.00

Design of Experiments for Pharmaceutical Product Development

$149.00

Mechanics and Physics of Energy Density

$129.00

Programmierte Einfhrung in die Wahrscheinlichkeitsrechnung

$54.99

Socially-critical Environmental Education in Primary Classrooms

$39.99

Soft Computing in Communications

$169.99

A Cultural History of Late Meiji Japan

$129.99

Managing Persistent Organic Pollutants in India

$139.99

Electrical Systems and Mechatronics

$49.99

Magic Tree House: #13 Vacation Under the Volcano

$5.21

Ocean Colour: Theory and Applications in a Decade of CZCS Experience

$84.99

Handbook of Philosophical Logic

$139.99

Deutsch-jdische Kinder- und Jugendliteratur von der Haskala bis 1945

$109.00

Understanding Willing Participants, Volume 1

$109.99

Changes in Work and Family Life in Japan Under COVID-19

$44.99

Praxis solarthermischer Kraftwerke

$119.99

Psychoses of the Schizophrenic Spectrum in Twins

$54.99

Neurosurgical Re-Engineering of the Damaged Brain and Spinal Cord

$109.99

Engage, Excel, and Elevate with Microsoft Viva Engage

$22.99

Advances in Physical Agents

$169.99

American Playwriting and the Anti-Political Prejudice

$89.00

Nanotechnology for Defence Applications

$84.99

International Handbook of Self-Study of Teaching and Teacher Education Practices

$629.00

Case Studies in Infrastructure Delivery

$109.99

Hybrid Artificial Intelligent Systems

$139.99

Atlas of the Supraaortic Craniocervical Arterial Variations

$199.99

Luminescent Materials

$139.00

US-Grenada Relations

$54.99

Facharztwissen Urologie

$109.00

Oncology

$169.00

Unsichtbar im Sturm

$29.99

Large-Scale Disk Failure Prediction

$39.99

Visual Behavior in Salamanders

$109.00

Heavy Metal Music, Texts, and Nationhood

$129.99

Das Kommunikationsmanagement von Werbeagenturen

$59.99

Zwischen Notwendigkeit und Kontingenz

$69.99

Countering Violent Extremism by Winning Hearts and Minds

$84.99

Regional Analgesia in Obstetrics

$109.99

RF/Microwave Hybrids

$129.00