Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Statistical Monitoring of Clinical Trials

Statistical Monitoring of Clinical Trials

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9780387300597
Condition
New
Product Description

The approach taken in this book is to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion (the B-value) irrespective of the test statistic. The so-called B-value approach to monitoring allows us to use, for different types of trials, the same boundaries and the same simple formula for computing conditional power. Although Brownian motion may sound complicated, the authors make the approach easy by starting with a simple example and building on it, one piece at a time, ultimately showing that Brownian motion works for many different types of clinical trials. The book will be very valuable to statisticians involved in clinical trials. The main body of the chapters is accessible to anyone with knowledge of a standard mathematical statistics text. More mathematically advanced readers will find rigorous developments in appendices at the end of chapters. Reading the book will develop insight into not only monitoring, but power, survival analysis, safety, and other statistical issues germane to clinical trials. Michael Proschan, Gordon Lan, and Janet Wittes are elected Fellows of the American Statistical Association. All have spent formative years in the Biostatistics Research Branch of the National Heart, Lung, and Blood Institute (NHLBI/NIH). While there, they were intimately involved in the design and statistical monitoring of large-scale randomized clinical trials, developing methodology to aid in their monitoring. For example, Lan developed, with DeMets, the now widely-used spending function approach to group sequential designs, whose properties were further investigated byProschan. The B-value approach used in the book was introduced in a very influential paper by Lan and Wittes. The statistical theory behind conditional power was developed by Lan, along with Simon and Halperin, and was the cornerstone for the conditional error approach to adaptive clinical trials introduced by Proschan and Hunsberger. All three authors have expertise in adaptive methodology for clinical trials. Michael Proschan is a Mathematical Statistician at the National Institutes of Health; Gordon Lan is Senior Director of Biometrics at Johnson & Johnson Pharmaceutical Research and Development, L.L.C.; Janet Wittes is President of Statistics Collaborative, a statistical consulting company she founded in 1990.

Available Colors
Available Sizes
1 Offer Price Range: $39.99 - $39.99
BEST PRICE

Single Product Purchase

$36.00
@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$39.99 $39.99

10% OFF
This deals requires coupon Get Code Here
$36.00
See Site In stock Visit Store

Similar Products

Mechanics of Composite, Hybrid and Multifunctional Materials, Volume 5

$249.99

Urinary Fistula

$119.99

Public and Private Social Policy

$54.99

Politische Bildung in Fotoromanen von Jugendzeitschriften

$64.99

ASEAN Financial Co-Operation

$44.99

Energy Resources in East Africa

$169.99

Prozessexzellenz im HR-Management

$109.00

Realisierung der Einsparpotentiale bei elektrischen Energieverbrauchern

$34.99

Multimodal Texts in Disciplinary Education

$59.99

Bioremediation and Biotechnology, Vol 2

$199.99

Beginning jQuery

$24.99

Elektrische Schweitechnik

$59.99

Advanced Catalytic Materials: Current Status and Future Progress

$109.99

The End of Oz (Dorothy Must Die Series #4) by Danielle Paige

$15.99

Intelligent Computer Graphics 2012

$109.99

Diseases at the Wildlife - Livestock Interface

$199.99

Chinas Provincial Economic Competitiveness and Policy Outlook for the 13th Five-year Plan Period (2

$54.99

Plants as Factories for Protein Production

$169.99

Create Web Charts with D3

$24.99

The Rumen Protozoa

$119.00

Cancer and the Heart

$74.99

Heat Pump Controls to Exploit the Energy Flexibility of Building Thermal Loads

$169.99

Urban Socio-Economic Segregation and Income Inequality

$59.99

My Daddy

$5.99

Frankreich und das vereinigte Deutschland

$59.99

Solving Problems in Food Engineering

$69.99

Syphilis

$39.99

Nile and Grand Ethiopian Renaissance Dam

$199.99

Unternehmensmodellierung

$64.99

Silicon Biomineralization

$169.99

Regimezerfall durch strategisches Steuerungsversagen

$74.99

Neural Engineering

$109.00

Compiler Construction

$39.99

Novel Bioinspired Actuator Designs for Robotics

$139.99

Ion-Irradiation-Induced Damage in Nuclear Materials

$84.99

Meteorological Satellite Systems

$39.99

R&D Management in the Knowledge Era

$169.99

Handbook of Literacy in Diglossia and in Dialectal Contexts

$169.99

High Performance Computing - HiPC 2007

$84.99

Technologie der Zukunft

$69.99