Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

The Pulmonary Neuroepithelial Body Microenvironment

The Pulmonary Neuroepithelial Body Microenvironment

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030658168
Condition
New
Product Description

This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.

Available Colors
Available Sizes
1 Offer Price Range: $89.00 - $89.00
BEST PRICE

Single Product Purchase

$89.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$89.00 $89.00

$89.00
See Site In stock Visit Store

Similar Products

Boy, Were We Wrong About Dinosaurs!

$6.71

Verletzungen des Schultergelenks

$69.99

Flower Garden: 6-Book Set

$30.95

Britain and the Marshall Plan

$54.99

The Ultimate Experience

$169.99

Systems Programming in Unix/Linux

$99.99

Moderate Alcohol Consumption and Cardiovascular Disease

$109.99

ICT for a Better Life and a Better World

$109.99

Banking 5.0

$179.99

Advanced Spatial Statistics

$169.00

Marketing im Zeitalter der Compunications

$69.99

Indigenous Methodologies, Research and Practices for Sustainable Development

$169.99

Grenzen der Behandlung

$69.99

Reframing Education as a Public and Common Good

$89.99

DESider A European Effort on Hybrid RANS-LES Modelling

$219.99

Feldionen-Massenspektrometrie an Kohlenwasserstoffen und Zwischenprodukten ihrer Verbrennungsreaktio

$59.99

Umweltschutztechnik

$69.99

Foreign Direct Investment Inflows Into the South East European Media Market

$109.99

Ethics of Socioeconomics

$59.99

Eat Right to Be Your Best

$3.71

Dynamic Optimization

$109.99

Gender, Citizenship and Newspapers

$54.99

Vegetation und Klima

$49.99

Dissociative Identity Disorder

$219.99

Bau groer Elektrizittswerke

$49.99

Computational Social Networks

$109.99

Biology of Vascular Smooth Muscle: Vasoconstriction and Dilatation

$129.00

Proceedings of International Conference on Computational Intelligence, Data Science and Cloud Comput

$299.99

EveryBody Tells A Story

$49.99

The Nature of Syntactic Representation

$329.99

Ubicomp 2001: Ubiquitous Computing

$39.99

Asking to Die: Inside the Dutch Debate about Euthanasia

$109.99

Secularism and its Opponents from Augustine to Solzhenitsyn

$54.99

Personalwirtschaft zwischen Bindung und Autonomie

$49.99

The Evaluation of Beat Blocker and Calcium Antagonist Drugs

$54.99

Advances in Aerobiology

$39.99

Fit in Biochemie

$44.99

Representation, Inclusion, and Innovation

$64.99

Modernizing the Role of the International Court of Justice

$129.99

Treaties and Executive Agreements in the United States

$54.99