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Serotonin und akustisch evozierte Potentiale

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Brand
Springer Nature
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N/A
Part Number
0
GTIN
9783798515482
Condition
New
Product Description

Bislang steht fr das serotonerge System beim Menschen kein valider Indikator zur Verfgung. Es gibt nun verschiedene Hinweise darauf, dass die Lautstrkeabhngigkeit der akustisch evozierten N1/P2-Komponente (LAAEP) als ein solcher Indikator in Frage kommt: Eine starke LAAEP zeigt eine niedrige serotonerge Aktivitt, eine schwache LAAEP zeigt eine hohe serotonerge Aktivitt. Ziel der hier beschriebenen Untersuchungen war es, diese Hypothese zu untermauern. Die Befunde belegen den Zusammenhang von LAAEP und dem serotonergen System und seine Spezifitt. Entscheidend ist dabei auch die Ntzlichkeit der LAAEP als Indikator des serotonergen Systems bei wichtigen klinisch-psychiatrischen Fragestellungen, beispielsweise der Prdiktion der individuellen Ansprechwahrscheinlichkeit auf Antidepressiva oder Rezidivprophylaktika. Eine Reihe von erfolgreichen Studien hierzu drfte die baldige Einfhrung der LAAEP in die klinische Praxis rechtfertigen.

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