Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Analyzing T Cell Responses

Analyzing T Cell Responses

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781402036231
Condition
New
Product Description

Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer vaccine strategy, a surrogate immunological end-point that correlates with clinical outcome needs to be defined, since it would facilitate the rapid comparison of these various formulations. Traditional immunological assays such as ELISA, proliferation and cytotoxicity assays can detect immune responses in vaccinated patients but are not quantitative. In contrast, novel assays such as enzyme-linked immunospot (ELISPOT) assay, intracellular cytokine assay and tetramer assay can quantitate the frequency of antigen-specific T cells. Of these, the ELISPOT assay has the 5 lowest detection limit with 1/10 peripheral blood mononuclear cells (PBMC) and has been determined to be one of the most useful assays to evaluate immune response to cancer vaccines (4). However, the IFN-? ELISPOT assay is not an exclusive measure of cytotoxic T-lymphocyte (CTL) activity as non-cytotoxic cells can also secrete IFN-?. Additionally, CTL with lytic activity do not always secrete IFN-? (5). A more relevant approach to assess functional activity of cytotoxic lymphocytes would be to measure the secretion of molecules that are associated with lytic activity. One of the major mechanisms of cell-mediated cytotoxicity involves exocytosis of cytoplasmic granules from the effector toward the target cell.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Verstehen als Konstruktion

$59.99

REACH Beyond Borders

$109.99

Sustainable and Energy Efficient Computing Paradigms for Society

$109.99

Industrialization, Trade and Market Failures

$109.99

Structured Object-Oriented Formal Language and Method

$44.99

Elektronische Gertetechnik

$44.99

Constructive Theory of Functions of Several Variables

$34.99

Advanced Connection Systems for Architectural Glazing

$39.99

Sensemaking und Sensegiving in der Sanierung

$64.99

Jahrbuch der Motorluftschiff-Studiengesellschaft

$59.99

Our Beautiful Moon and its Mysterious Magnetism

$64.99

Bewertung von Kernkompetenzen

$79.99

Chemische Produkte aus Erdl

$34.99

Forthcoming Networks and Sustainability in the IoT Era

$169.99

Machine Learning and Data Mining Approaches to Climate Science

$169.99

Junge Ostdeutsche auf der Suche nach der Freiheit

$64.99

Crossing Fandoms

$64.99

Energy Management of Internet Data Centers in Smart Grid

$54.99

Duftgelenkte Bienen im Dienste der Landwirtschaft und Imkerei

$6.99

Trends in Intelligent Systems and Computer Engineering

$169.99

Enterprise, Business-Process and Information Systems Modeling

$54.99

Reliability and Optimization of Structural Systems 90

$169.99

A Parallel Algorithm Synthesis Procedure for High-Performance Computer Architectures

$109.99

Lone Parenthood in the Life Course

$59.99

Soil Mechanics

$54.99

Fnfstellige Funktionentafeln

$59.99

Romanticism, Sincerity and Authenticity

$39.99

Combinatorics, Computability and Logic

$109.99

The Context of Medicines in Developing Countries

$249.99

Risikomanagement in Verbnden

$69.99

Informatics in Control, Automation and Robotics

$84.99

The Hidden Barriers and Enablers of Team-Based Ideation

$49.99

Empirical Science of Financial Fluctuations

$109.99

From Psycho-Analysis to Culture-Analysis

$99.99

Internationalisation of Logistics Systems

$109.99

Die verschiedenen Versicherungszweige

$59.99

The Southwest Economy in the 1990s: A Different Decade

$54.99

Youth, Inequality and Social Change in the Global South

$54.99

Competitive-cum-Cooperative Interfirm Relations and Dynamics in the Japanese Semiconductor Industry

$39.99

Orientierungen politischer Bildung im "postfaktischen Zeitalter"

$44.99