Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Lead-Seeking Approaches

Lead-Seeking Approaches

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783642010743
Condition
New
Product Description

High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [16].

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Supply Management Research

$44.99

Anaesthesia, Pain, Intensive Care and Emergency Medicine A.P.I.C.E

$109.99

International Corporate 1000 Yellow Book

$54.99

Vegetation Fires and Pollution in Asia

$169.99

Der diabetische Fu

$79.99

Leipziger mathematische Antrittsvorlesungen

$69.95

Pediatric Surgical Diseases

$219.99

Proteases and Their Receptors in Inflammation

$169.99

Modelle und Modellierungsverfahren in der Fahrzeugdynamik

$39.99

Liberal Internationalism

$109.99

Basiswissen betriebliche Steuerlehre

$17.99

Six Crises of the World Economy

$99.00

The Demography of Disasters

$49.99

Testing and Tuning Market Trading Systems

$44.99

Finance for Engineers

$129.99

Surface Microscopy with Low Energy Electrons

$169.99

ber das Vitamin C in Kuh- und Frauenmilch und die Mglichkeit der Herstellung einer Vitamin C-Milch

$49.99

Breaking Through

$54.99

Boko Haram and International Law

$169.00

Stahlfaserbeton

$54.99

Ethics and Self-Knowledge

$109.99

Rostfreie Sthle

$59.99

The Economic Geography of Cross-Border Migration

$199.99

Untersuchungen ber die automatische Lsung von Aufgaben der konstruktiven Geometrie

$59.99

Encyclopedia of Fermented Fresh Milk Products: An International Inventory of Fermented Milk, Cream

$219.99

Indoor Sound Environment and Acoustic Perception

$179.99

A Science-Based Critique of Epistemological Naturalism in Quines Tradition

$39.99

Advances in PET

$64.99

Nonlinear Problems in Mathematical Physics and Related Topics II

$109.99

OSU PreK Pack (15)

$79.94

Quick Guide Social Relations

$29.99

Mobile Learning in Higher Education in the Asia-Pacific Region

$169.99

Endoscopic Sinus Surgery

$39.99

Lieferantenfinanzierung im Telekommunikationsmarkt

$59.99

Electron and Ion Optics

$149.00

Social Media Processing

$39.99

Handbook of Geometry and Topology of Singularities II

$149.00

The Social Audit Consumer Handbook

$19.99

Tattoos und Tattooentfernung

$19.99

Shield Tunnel Cutter Replacement Technology

$159.99