Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Problems of High Altitude Medicine and Biology

Problems of High Altitude Medicine and Biology

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781402062988
Condition
New
Product Description

The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].

Available Colors
Available Sizes
1 Offer Price Range: $219.99 - $219.99
BEST PRICE

Single Product Purchase

$198.00
@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$219.99 $219.99

10% OFF
This deals requires coupon Get Code Here
$198.00
See Site In stock Visit Store

Similar Products

Partielle Differentialgleichungen

$39.99

Animals Helping to Detect Diseases (A True Book: Animal Helpers)

$5.21

The Works of Claudio Magris: Temporary Homes, Mobile Identities, European Borders

$54.99

Konstruierte Normalitten - normale Abweichungen

$59.99

Kalkulation und Preisbildung in Bauunternehmen

$99.00

New Activism and the Corporate Response

$54.99

Mittelalterliche Fachliteratur

$29.99

Historical Archaeology in Wachovia

$39.99

Philosophy and Child Poverty

$84.99

Erfahrungen deutsch-chinesischer Joint Ventures

$69.99

Kent and Riegel's Handbook of Industrial Chemistry and Biotechnology

$249.00

Illustrated Handbook of Cardiac Surgery

$159.99

Philosophical Investigations in the U.S.S.R

$54.99

Evolutionary Optimization: the GP toolkit

$84.99

Excimer Laser Technology

$299.99

Counterterrorism in Areas of Political Unrest

$39.99

3D Graphene

$189.00

Jack Kerouac and the Literary Imagination

$54.99

Die Bankgehilfenprfung in Frage und Antwort

$59.99

Promoting Collaborative Learning Cultures to Help Teachers Support Students with Autism Spectrum Dis

$119.00

Metabolic Profiling

$119.00

Die Bedeutung von Institutionen fr die Weiterbildung lterer

$44.99

Dying and Dead Seas Climatic Versus Anthropic Causes

$219.99

The Diffusion of Power in Global Governance

$39.99

Arbeiten im Sozialraum

$59.99

Interneteinsatz in der betriebswirtschaftlichen Aus- und Weiterbildung

$59.99

Evolution and Ethics

$54.99

Rethinking Asian Capitalism

$179.99

Kompakt-Lexikon Wirtschaftstheorie

$19.99

Proceedings of the Munich Symposium on Lightweight Design 2020

$179.99

The Meaning of Leisure

$99.99

Communication and Peace

$54.99

Nutzen, Nicht-Nutzen und Nutzung Sozialer Arbeit

$44.99

A Managers Primer on e-Networking

$39.99

Encyklopdie der Mathematischen Wissenschaften mit Einschluss ihrer Anwendungen

$84.99

Introducing Spring Framework

$34.99

Privatization and Entrepreneurship in Post-Socialist Countries

$39.99

Monopole 83

$39.99

The LGM Distribution of Dominant Tree Genera in Northern China's Forest-steppe Ecotone and Their Pos

$109.99

Adhesion and Adhesives

$329.99