Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Problems of High Altitude Medicine and Biology

Problems of High Altitude Medicine and Biology

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781402062988
Condition
New
Product Description

The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].

Available Colors
Available Sizes
1 Offer Price Range: $219.99 - $219.99
BEST PRICE

Single Product Purchase

$219.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$219.99 $219.99

$219.99
See Site In stock Visit Store

Similar Products

Transportation Planning for a Better Environment

$39.99

The Silicon Valley Model

$64.99

New Aspects of Magellanic Cloud Research

$84.99

Denken und Dichten des Seins

$79.99

The Changing Profile of the Natural Law

$99.00

Viruses: Essential Agents of Life

$169.99

Extremal Combinatorics

$99.99

Epidemiologic Research on Real-World Medical Data in Japan

$54.99

Legal Engineering in the Supervisory System Reform

$179.99

Computergesteuerte Spielpartner

$64.99

Internationalizing the Social Sciences in China

$139.99

The Right Ventricle

$259.00

Japan versus China in the Industrial Race

$54.99

Die Netzwerkarchitektur SNA

$54.99

Thoracoscopy for Pulmonologists

$84.99

Ubiquitous Information Technologies and Applications

$219.99

Mitarbeiterfhrung mit dem LEAD-Navigator

$39.99

Allgemeine Versicherungslehre

$59.99

Peer-to-Peer Computing

$84.99

Beyond the BBC

$29.99

Not Yet: The Story of an Unstoppable Skater (Hardcover)

$14.24

The Timing of Toxicological Studies to Support Clinical Trials

$84.99

The Sodium-Hydrogen Exchanger

$109.99

Turbulente Strmungen

$39.99

Vibrations of mechanical systems with regular structure

$169.99

William Blake and the Daughters of Albion

$84.99

Engaging Men in the Fight against Gender Violence

$39.99

Metaheuristics for Business Analytics

$39.99

Hello Seasons!: Hello Spring!

$5.96

Future Wireless and Optical Networks

$109.99

Child Survival

$219.99

Political Communication in Britain

$32.99

Economic Theory of Public Enterprise

$54.99

Glibber, Glimmer, Laserschwerter: Chemie-Experimente zuhause

$24.99

The New Bail-In Legislation

$69.99

Tissue Engineering, Stem Cells, and Gene Therapies

$169.00

Mut zur Vernderung

$49.99

Endocytosis and Signaling

$179.99

Integral Transforms in Science and Engineering

$54.99

Recovery from the Indian Ocean Tsunami

$169.99