Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Optimization in Drug Discovery

Optimization in Drug Discovery

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781592598007
Condition
New
Product Description

Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential. Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on.

Available Colors
Available Sizes
1 Offer Price Range: $119.00 - $119.00
BEST PRICE

Single Product Purchase

$119.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$119.00 $119.00

$119.00
See Site In stock Visit Store

Similar Products

Applied Hydrodynamics in Petroleum Exploration

$169.99

Elektroakustik

$69.99

Curriculum Sozialarbeit/Sozialpdagogik in Nordrhein-Westfalen

$59.99

Recoverable Mutual Exclusion

$34.99

Emerging Personal Wireless Communications

$129.00

The Comprehensive Classification of Fractures of Long Bones

$54.99

Intentionalitt als Verantwortung

$84.99

Biomechanics of the Normal and Diseased Hip

$74.99

Sensation and Sublimation in Charles Dickens

$39.99

Supportive Cancer Care

$109.99

Recent Trends in Wave Mechanics and Vibrations

$219.99

Steinkohlenteer

$59.99

Advanced Functional Materials from Nanopolysaccharides

$169.99

kologie in Zahlen

$34.99

The Dumb Bunnies Go To The Zoo (Hardcover)

$12.74

Die Gesellschaft der Leute

$29.99

Differential Operators on Manifolds

$49.95

Climate Change and Future Rice Production in India

$109.99

Understanding Pottery Function

$54.99

Congress on Intelligent Systems

$129.00

Expert Visual C++/CLI

$39.99

Stink Bugs (Hemiptera: Pentatomidae) Research and Management

$219.99

Competitive-cum-Cooperative Interfirm Relations and Dynamics in the Japanese Semiconductor Industry

$39.99

Der Fu des Lufers

$22.99

The War Against Nonhuman Animals

$139.99

Time-Integrative Geographic Information Systems

$109.99

The Cast Iron Skillet Cookbook - A Tantalizing Collection of Over 200 Delicious Recipes for Every Kitchen by Dominique Devito

$24.95

Mass Customization and Sustainability

$169.99

Strategische Prozesse und Pfade

$84.99

Jedem Kind sein Instrument

$39.99

Frontiers in Numerical Analysis

$54.99

Bacterial Diarrheal Diseases

$39.99

Migration and International Relations

$49.99

Imaginative Participation

$54.99

Ancient Hunting Strategies in Southern South America

$99.00

Digital Detox

$19.99

The History and Politics of Public Radio

$99.99

Proceedings of the 15th Scandinavian Congress Oslo 1968

$29.99

Volksreligion und Herrschaftskirche

$39.99

Polysaccharides as Battery Components

$54.99