Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Deoxynucleoside Analogs in Cancer Therapy

Deoxynucleoside Analogs in Cancer Therapy

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781588293275
Condition
New
Product Description

Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Available Colors
Available Sizes
1 Offer Price Range: $169.00 - $169.00
BEST PRICE

Single Product Purchase

$169.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$169.00 $169.00

$169.00
See Site In stock Visit Store

Similar Products

An Introduction to Fuzzy Logic for Practical Applications

$169.99

Channel Coding Techniques for Wireless Communications

$139.99

Risikomanagement in Versicherungsunternehmen

$29.99

Physik fr Biologen

$64.99

Spin-Orbit-Induced Spin Textures of Unoccupied Surface States on Tl/Si(111)

$84.99

Selenoproteins

$179.99

The Hyperbolic Map and Applications to the Linear Quadratic Regulator

$39.99

Particle Modeling

$109.99

A Practical Clinical Guide to Resin Cements

$109.99

ECOOP '87. European Conference on Object-Oriented Programming

$39.99

Die Donau als Europische Kraftwasserstrasse

$59.99

Domain Decomposition Methods in Science and Engineering XXII

$169.99

Reviews of Physiology, Biochemistry and Pharmacology 157

$109.99

Dimensionstheorie

$64.99

Die proximalen Humerusfrakturen

$79.99

Innovationsfrderung fr den Wettbewerb der Zukunft

$49.99

Problemorientiertes Management

$69.99

Praxishandbuch Chefentlastung

$54.99

Ecology of Ungulates

$219.99

Housing Markets and Housing Institutions: An International Comparison

$109.99

Plant Tissue Culture: New Techniques and Application in Horticultural Species of Tropical Region

$219.99

Advances in Best-Worst Method

$169.00

A Roadmap to Future Space Connectivity

$199.99

DNA Methyltransferases - Role and Function

$129.00

Personalbedarf und Kosten im Medizinischen Laboratorium

$44.99

Social Media as a Space for Peace Education

$109.99

Advances in Mitochondrial Medicine

$219.99

Physiology and Biochemistry of Plant Cell Walls

$169.99

Hawthorne, Gender, and Death

$54.99

Organometallics and Related Molecules for Energy Conversion

$109.99

Die Reorganisation der Fabrik und die Wiederentdeckung der Arbeit

$69.95

Dielectric Properties of Porous Media

$109.99

Multivariate Analysemethoden

$54.99

Process Analytical Chemistry

$219.99

Spontaneous Formation of Space-Time Structures and Criticality

$329.99

Melba

$39.99

Environmental Issues in Supply Chain Management

$169.99

Biomechanical Models for Soft Tissue Simulation

$54.99

Parameter Setting in Evolutionary Algorithms

$219.99

Vom Nothilfeprogramm zur Normensetzung

$39.99