Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Hypoxia and Cancer

Hypoxia and Cancer

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781461491668
Condition
New
Product Description

The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype.Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation.HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is atopic hasbeen gaining scientific interestover the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Ages, Generations and the Social Contract

$169.99

Survival or Extinction?

$39.99

Klopstock/Milton - Teleskopie der Moderne

$49.99

Drugs from Nature: Targets, Assay Systems and Leads

$169.99

Topological Rings Satisfying Compactness Conditions

$109.99

CAPM in Depth

$59.99

The Institutionalization of Divestitures

$59.99

Advances in Nutritional Research Volume 10

$169.99

Genre-based Automated Writing Evaluation for L2 Research Writing

$109.99

Functional Imaging and Modeling of the Heart

$39.99

Computational Science/Intelligence and Applied Informatics

$84.99

System Modelling and Optimization

$39.99

Bewertungen in Umweltschutz und Umweltrecht

$74.99

The Psychology of Authoritarian Leaders

$169.99

The Politics of Expertise in Latin America

$169.99

Large-Scale Transport Processes in Oceans and Atmosphere

$129.00

Global, Regional and Local Perspectives on the Economies of Southeastern Europe

$199.99

Neuropdiatrie

$59.99

Recht fr Bankfachwirte

$34.99

Lernen von Finnland

$89.99

Vertrieb im Systemgtergeschft

$59.99

Grundlagen Automatisierung

$29.99

National Wildlife Federation Field Guide to Birds of North America by Edward S. Brinkley

$24.95

Fire Behavior and Fire Protection in Timber Buildings

$169.99

Krippenerziehung in der DDR

$59.99

Produktion und Umwelt

$49.99

Modeling and Control of Power Electronic Converters for Microgrid Applications

$79.99

Total Colourings of Graphs

$29.99

Brgerenergie in Deutschland

$64.99

Analysing Society in a Global Context

$54.99

Information Systems and Outsourcing

$84.99

Advances in Stochastic Simulation Methods

$84.99

Business Cycles and Structural Change in South Africa

$109.99

Die Turbinen-Versuchsstationen und die Wasserkraft-Zentralen mit hydraulischer Akkumulierungsanlage

$59.99

Stochastic Processes and Long Range Dependence

$129.99

Learning Trajectories, Innovation and Identity for Professional Development

$109.99

Herbert Hoover and Dwight D. Eisenhower

$54.99

Militrische Auslandseinstze

$39.99

Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye

$119.99

The Comedians in Cars Getting Coffee Book by Jerry Seinfeld

$35.00