Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Genetic Basis for Respiratory Control Disorders

Genetic Basis for Respiratory Control Disorders

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9780387707648
Condition
New
Product Description

Genetic Basis for Respiratory Control Disorders provides an overview of the recent knowledge of the genetic factors underlying respiratory control disorders, an emerging field in respiratory biology. Identifying genes involved in respiratory control is crucial for understanding human diseases characterized by abnormal respiratory control, such as Prader-Willi syndrome, Rett syndrome, congenital central hypoventilation syndrome (CCHS), obstructive sleep apnea syndrome (OSAS), central sleep apnea syndrome, apneas of prematurity and sudden infant death syndrome (SIDS). Furthermore, genetic factors play a key role in respiratory control adaptation in health and disease, most notably in the respiratory response to intermittent hypoxia. The objective of the book is to supply state-of-the-art contributions about all aspects of respiratory control genetics, from the molecular to the system level. The book aims to review the full spectrum of available knowledge, which starts with early physiological studies in health and disease in humans and studies in rodents that suggested a hereditary component to respiratory control. The spectrum extends to recent work elucidating crucial molecular aspects of respiratory control development, from early embryonic specifications in the neural tube to the function of respiratory rhythm generators. Developmental programs and gene expression profiles of different neuron types in the respiratory-control neuronal network have been characterized, together with their control by specific sets of transcription factors. In mice, targeted inactivation of several transcription factors disrupts the development of specific respiratory-neuron groups and causes abnormal respiratory phenotypes. These effects are described in detail in the book, with . a special attention to was given to the role of the transcription factor Phox2b. The developmental and respiratory phenotypes in newborn mice with Phox2b gene deletion and in vitro investigations of human mutated PHOX2B proteins have shed light on the pathogenesis of CCHS. Respiratory control abnormalities in necdin-null mice and in mice lacking Mecp2 gene have provided new insights into the developmental origins of the respiratory disorders seen in Prader-Willi and Rett syndromes, respectively. Current genetic data in complex and multi-factorial respiratory disorders, including SIDS and OSAS, are described. Genetic Basis for Respiratory Control Disorders emphasizes the potent synergy between human studies and mouse models of genetic disorders underlying respiratory control anomalies. The overview of current research presented in this book opens up the field to the development of new therapeutic strategies, especially in newborns and infants, who are the primary target of respiratory control disorders. This book is addressed to pediatricians, neonatologists, pulmonologists, respiratory physiologists as well as geneticists.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$116.10
@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

10% OFF
This deals requires coupon Get Code Here
$116.10
See Site In stock Visit Store

Similar Products

Women's Reproductive Rights

$109.99

Einfhrung Mathematik Primarstufe Geometrie

$39.99

Information and Communication Technology (ICT) Frameworks in Telehealth

$39.99

Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrs des recherches pharmace

$39.99

Der Springer-Verlag

$44.99

Quarks and Leptons From Orbifolded Superstring

$54.99

The Night I Forgot to Brush / La noche que olvid cepillarme los dientes

$3.71

Chefsache Frauen

$29.99

Smart Health rechtsvertrglich gestaltet

$49.99

Vasovagal Syncope

$109.99

Defect and Material Mechanics

$109.99

Recent Advances in Modeling Landslides and Debris Flows

$109.99

Privacy vs. Security

$39.99

Intellectual Pursuits of Nicolas Rashevsky

$109.99

Data Driven Approach Towards Disruptive Technologies

$329.99

Kongenitale Strungen des Wasser- und Elektrolythaushaltes

$59.99

Die Fertigungsbelange des Gesenkschmiedens und ihre wissenschaftliche Weiterentwicklung

$49.99

Recent Advances in Mechanical Infrastructure

$169.99

The ECU and European Monetary Integration

$129.00

Die Freiwilligen Feuerwehren in sterreich und Deutschland

$74.99

Algorithms and Architectures for Parallel Processing

$54.99

Theory of Elastic Waves

$179.99

Carbon Nanotubes

$84.99

President Obama and Education Reform

$54.99

Sustainable Agriculture Reviews 42

$169.99

The Phylogenetic System of Ephemeroptera

$219.99

Enjoyment

$169.99

Die neue Neurootologie

$79.99

Challenging Dominant Views on Student Behaviour at School

$109.99

Fractals in Biology and Medicine

$34.99

Biochemical Differentiation in Insect Glands

$39.99

The Valuation of Digital Intangibles

$169.99

Scaling Social Impact

$54.99

Grundkurs Analysis und Lineare Algebra

$29.99

Link Theory in Manifolds

$39.99

Beatrice And Sidney Webb

$19.99

Die Vorbereitung zu Chirurgischen Eingriffen

$59.99

Emerging Organic Pollutants in Waste Waters and Sludge

$169.00

User-Developer Cooperation in Software Development

$109.99

Literature and Philosophy

$54.99