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Copper-Catalyzed Electrophilic Amination of sp2 and sp3 CH Bonds

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Springer Nature
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N/A
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GTIN
9783319388786
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New
Product Description

This thesis reports the latest developments in the direct amination of various CH bonds using an HZn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved CH zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source. McDonalds findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.

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