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Transporters in Drug Development
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Transporters in Drug Developmentexamines how membrane transporters can be dealt with in academicindustrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in theintestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlightsperspectives of applying targeted proteomics and mechanistic modeling in this process.
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