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Zytokinregulation bei chronischer Herzinsuffizienz, extrakorporaler Zirkulation und Herztransplantat

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Brand
Springer Nature
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N/A
Part Number
0
GTIN
9783798510784
Condition
New
Product Description

Die vorliegende Habilitationsschrift untersucht die Hypothese, da die Pumpstrung des Herzens bei Herzinsuffizienz, extrakorporaler Zirkulation und frh nach Herztransplantation eine gemeinsame immunologische Komponente umfat. Die direkten Beziehungen zwischen dem Immunsystem und den klassischen Determinanten der kardialen Pumpfunktion, d.h. der Vorlast, Nachlast, Kontraktilitt und Herzfrequenz, werden kritisch diskutiert. Sie werden als mgliche gemeinsame biologische Endstrecke verschiedener pathophysiologischer Konstellationen, von der asymptomatischen linksventrikulren Dysfunktion bis hin zum Sepsis-Syndrom und Multi-Organ-Versagen, interpretiert. Die vorliegende Arbeit, die im interdisziplinren Konzept des Herzzentrums Mnster entstand, stellt einen originellen fachbergreifenden Denkansatz dar. Dieser ist fr Kardiologen, Herzchirurgen, Ansthesiologen und Intensivmediziner gleichermaen von Bedeutung. Er wird in Zukunft im rztlichen Alltag zu einem verbesserten Verstndnis der kardialen Pumpstrung unterschiedlicher Genese sowie zur Entwicklung von neuen Mglichkeiten der Erkennung und Behandlung beitragen.

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