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In-vitro- und in-vivo-Untersuchungen zur selektiven Immunadsorptionsbehandlung neurologischer Erkran

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Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783642770937
Condition
New
Product Description

Plasmaaustauschverfahren gehren zum therapeutischen Instrumentarium schwerer Zustandsbilder neuroimmunologischer Erkrankungen wie z.B. Myasthenia gravis und chronische Polyneuritis. Nachteilig ist, da dabei unselektiv smtliche Plasmaproteine entfernt werden und durch Fremdprotein substituiert werden mssen. Ein neuentwickeltes Adsorptionsgel, bestehend aus gekrntem Polyvinylalkohol und kovalent gebundenem Tryptophan zeigte in vitro selektive Adsorptionseigenschaften fr die bei der Myastenia gravis pathogenen Autoantikrper. Die Adsorption fand ber hydrophobe Wechselwirkungen zwischen den Antikrpern und dem Gelmaterial statt. Fnfzehn Patienten mit schwerer Myasthenia gravis und drei Patienten mit chonischer Polyneuritis wurden in vivo mit dem Immunadsorptionsverfahren behandelt, wobei die Patienten ihr eigenes, an pathogenen Substanzen verarmtes Plasma zurckerhielten. Die klinischen Erfolge waren durchweg gut und erwiesen sich bei fnf cross-over Vergleichen als gleichwertig mit Plasmaaustauschbehandlungen. Das Immunadsorptionsverfahren war gut vertrglich. Das Immunadsorptionsverfahren kann die therapeutischen Optionen bei neuroimmunologischen Erkrankungen erweitern und darber hinaus weitere pathogenetischen Erkenntnisse liefern.

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