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Clozapin Pharmakologie und Klinik eines atypischen Neuroleptikums
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Zu den wesentlichen Problemen der neuroleptischen Therapie schizophrener Patienten gehren Therapieresistenz, schizophrene Minussymptomatik und Rezidivprophylaxe. Zu allen drei Themen wird jeweils in einem allgemeinen Beitrag der Stand der Forschung berichtet, in einem speziellen Kapitel die Bedeutung von Clozapin dargestellt. Weitere Kapitel von klinischer Relevanz behandeln Probleme in der Akuttherapie mit Clozapin (Dosierung, Umstellung, Kombination mit anderen Neuroleptika, Nebenwirkungen) sowie Aspekte der Langzeitbehandlung und der Therapie durch den niedergelassenen Psychiater.
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