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Modellierung zellulrer Gliomwachstumsprozesse in ihrer Mikroumgebung

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Brand
Springer Nature
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GTIN
9783658046835
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New
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Krebs ist eines der weitverbreitetsten Krankheitsbilder im Erwachsenenalter und steht zunehmend im Zentrum unterschiedlicher wissenschaftlicher Disziplinen. Alina Toma befasst sich mit der mathematischen Modellierung der Progression des Glioblastoms. Fr eine realittsnahe Simulation des zellulren Wachstums des Tumors bercksichtigt sie Umgebungsfaktoren wie Nhrstoffe und die extrazellulre Matrix. Sie betrachtet neben Migration und Proliferation von Tumorzellen weitere Zellstatus wie Zelltod oder Ruhezustand. Die Autorin integriert zum ersten Mal die Immunzellen des zentralen Nervensystems in ein Glioblastom-Wachstumsmodell, wobei sie relevante in-vitro Experimente zur Validierung des Modells hinzufgt. Die Arbeit fhrt in die Strahlentherapie und Multiskalenmodellierung ein und greift die wichtigen Aspekte der Tumormikroumgebung auf, um so eine realistische Darstellung der Wachstumsprozesse abzubilden.

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