Copied Gene Therapeutics
Gene Therapeutics
During the first half century of genetics, coinciding with the first half of this cen tury, geneticists dreamt of the repair of genetic disease by altering or replacing defective genes. H. J. Muller wrote of the great advantages of mutations, "nanoneedles" in his apt term, for delicately probing physiological and chemical processes. In the same spirit, genes could be used to provide treatments of needle point delicacy. Yet, during this period no realistic possibility appeared; it remained but a dream. The situation changed abruptly at the half century. Microbial genetics and its offshoot, cell culture genetics, provided the route. Pneumococcus transformation showed that exogenous DNA could become a permanent part of the genome; yet attempts to reproduce this in animals produced a few tantalizing hints of success, but mostly failures. Transduction, using a virus as mediator, offered a better op portunity. The fITSt reproducible in vivo gene therapy in a whole animal came in 1981. This was in Drosophila, with a transposable element as carrier. Flies were "cured" of a mutant eye color by incorporation of the normal allele, and the effect was transmissible, foreshadowing not only somatic, but germ line gene therapy. At the same time, retroviruses carrying human genes were found to be ex tremely efficient in transferring their contents to the chromosomes of cultured cells.
Price Comparison
| Seller | Contact Seller | List Price | On Sale | Shipping | Best Promo | Final Price | Volume Discount | Financing | Availability | Seller's Page |
|---|---|---|---|---|---|---|---|---|---|---|
|
BEST PRICE 1 Product Purchase
|
|
$39.99 | $39.99 |
|
$39.99 | See Site | In stock | Visit Store |
Reviews
Questions & Answers
Grundlagen der Theoretischen Informatik
$39.99
Child Rights to Guardianship
$109.00
Leitfaden Geometrie
$54.99
Statistical Mechanics for Engineers
$54.99
AO ASIF Principles in Spine Surgery
$129.00
Recent Progress in Many-Body Theories
$39.99
Variational Calculus and Optimal Control
$89.99
Politische Philosophie
$17.99
Global collaboration, local production
$59.99
The European Higher Education Area
$59.99
Human-Computer Interaction. Theoretical Approaches and Design Methods
$109.99
Verhandeln, kooperieren, werben
$79.99
The Spider Ring (Hardcover)
$12.74
Geometric Analysis and Applications to Quantum Field Theory
$39.99
Pediatric Compliance
$219.99
Slay
$8.99
Funktionentheorie 1
$39.99
Advances in Mechanical and Materials Technology
$299.99
Crisis, Adjustment and Growth in Uganda
$39.99
A Summary of Scientific Method
$44.99
Vuelta al juego
$5.21
Social Informatics
$79.99
Extrahepatic Manifestations in Liver Diseases
$219.99
Complexity, Analysis and Control of Singular Biological Systems
$84.99
Eurasian Business Perspectives
$109.99
Analytical Molecular Dynamics of Amorphous Condensed Matter
$109.99
The Biology of Mammalian Spermatogonia
$149.00
Optimal Time-Domain Noise Reduction Filters
$54.99
VLSI-SoC: System-on-Chip in the Nanoscale Era Design, Verification and Reliability
$54.99
Infrastructure and Productivity in Asia
$84.99
Medikamentse Glaukomtherapie
$59.99
The Use of First and Second Language in Chinese University EFL Classrooms
$54.99
Philosophical Problems of Statistical Inference
$109.99
Nachtrag zum Teil II: Sitzungsbericht
$54.99
Contemporary Hematology/Oncology
$109.99
Der Status der Unternehmung
$59.99
Neuromuskulre Lsionen bei Malignomen
$59.99
Testen, Analysieren und Verifizieren von Software
$59.99
Brian Selznick Grades 6-8
$72.00
Nature, Risk and Responsibility
$59.99
