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Der IL-1-Rezeptor-Antagonist im Zytokin-Netzwerk

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Brand
Springer Nature
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N/A
Part Number
0
GTIN
9783642537813
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New
Product Description

Die Ursachen der rheumatoiden Arthritis (RA) sind trotz intensiver Forschungsarbeiten immer noch nicht geklrt. Das Wissen um die Pathogenese hat in den letzten Jahren jedoch stark zugenommen. Die Identifizierung der Regelkreise im Zytokin-Netzwerk mit den einzelnen daran beteiligten Zytokinen war der entscheidende Schritt fr die Entwicklung spezifischer Therapieformen zur Behandlung rheumatischer Erkrankungen, insbesondere der RA. Interleukin-1 (IL-1) und Tumornekrosefaktor-a (TNF-allpha) sind die beiden Schlsselzytokine im pathologischen Geschehen der RA. IL-1 ist in erster Linie fr die destruktiven Ablufe und die Hemmung von Reparaturvorgngen an Knorpel und Knochen verantwortlich. Hier liegt der wesentliche Angriffspunkt des Interleukin-1-Rezeptor-Antagonisten (IL-1ra). Dieses Buch fasst sowohl Ergebnisse der Grundlagenforschung zur Rolle von Zytokinen bei der RA als auch klinische Erfahrungen bei der Therapie mit einem rekombinanten IL-1-Rezeptor-Antogonisten zusammen.

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