Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Human Immunodeficiency Virus Reverse Transcriptase

Human Immunodeficiency Virus Reverse Transcriptase

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781461472902
Condition
New
Product Description

The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable model system in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discussmechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.

Available Colors
Available Sizes
1 Offer Price Range: $89.00 - $89.00
BEST PRICE

Single Product Purchase

$89.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$89.00 $89.00

$89.00
See Site In stock Visit Store

Similar Products

Capturing the Mood of Democracy

$64.99

Choosing and Using Astronomical Filters

$39.99

Infants in Crisis

$39.99

Einfhrung in den praktischen Journalismus

$19.99

Scenarios, Fictions, and Imagined Possibilities in Science, Engineering, and Education

$219.99

Groforschung mit kleinen Teilchen

$69.99

Gabler Wirtschafts Lexikon

$89.99

Logical and Computational Aspects of Model-Based Reasoning

$109.99

Alternative Perspectives on Economic Policies in the European Union

$109.99

Nonlinear Mechanics of Complex Structures

$249.99

Lehrbuch des Stoffwechsels und der Stoffwechsel-Krankheiten

$49.99

Physics from Symmetry

$39.99

Exclamation Mark (Hardcover)

$14.24

Advances in Crowdsourcing

$39.99

Die rmische Petrustradition im Lichte der neuen Ausgrabungen unter der Peterskirche

$59.99

Archometrie

$49.99

Particle and Astroparticle Physics

$59.99

Spatial Processing in Navigation, Imagery and Perception

$169.99

Food Packaging: The Smarter Way

$109.00

Data Integration in the Life Sciences

$34.99

Atheistic Platonism

$139.99

Die Stolpe-Doktrin und ihre Anwendung auf verdeckte uerungen und Bildberichterstattungen

$119.99

The Role of Criticism in Understanding Problem Solving

$109.99

Mndliche Prfung Bilanzbuchhalter (IHK)

$39.99

Digitale Kommunikationssysteme 2

$54.99

Politics and Society in Hungary

$99.99

Residue Reviews

$84.99

Hyperbolic Functional Differential Inequalities and Applications

$84.99

Hip-Hop Revolution in the Flesh

$54.99

Beitrag zur Berechnung von Translationsschalen

$54.99

e-Infrastructure and e-Services for Developing Countries

$54.99

Reproduction in Transgender and Nonbinary Individuals

$119.99

Springer Series in Light Scattering

$99.00

Ford Madox Ford and the Misfit Moderns

$54.99

Understanding China's Overcapacity

$109.99

Incorporating Sustainability in Management Education

$109.00

Psychologische Untersttzung in der Strahlentherapie

$84.99

Computational Data and Social Networks

$64.99

Women Screenwriters

$219.99

The Palgrave Handbook of Gothic Origins

$189.00