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Von der Immunologie der humanen Ontogenese zur Immunologie der Onkogenese

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Springer Nature
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N/A
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GTIN
9783662696705
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New
Product Description

Der implantierende Embryo und die Zellen eines Malignoms stehen vor denselben Herausforderungen: zu einen mssen sie einen Angriff des Immunsystems effektiv abwehren und zum anderen bentigen sie mglichst viele externe Wachstumsimpulse. Diese erhalten sie u.a. von Immunzellen, die sie dafr aber erst instrumentalisieren, also umdrehen mssen. Die embryonale Implantation ist elementar, ebenso die zugrundeliegenden Mechanismen der immunologischen Kommunikation und Interaktion. Whrend das alles bei der embryonalen Implantation - blicherweise - geordnet abluft, sind die Zellen eines Malignoms in chaotischer Weise entdifferenziert und bedienen sich dieser Mechanismen demzufolge wenig vorhersehbar. Insofern lassen sich aus dem Grundverstndnis der embryonalen Implantation umfassende und personalisierte Diagnose- und Therapiekonzepte ableiten, v.a. fr die Onkologie.

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