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Neuartige Anstze fr die laserbasierte Manipulation von Zellen mit Hilfe plasmoneninduzierter Effek

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Springer Nature
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N/A
Part Number
0
GTIN
9783658177072
Condition
New
Product Description

Judith Krawinkel zeigt anhand von Goldnanostrukturen, dass deren Interaktion mit Laserstrahlung das Potenzial hat, schonend und effizient Wirkstoffe in Zellen einzubringen, diese gezielt zu eliminieren oder genetisch zu manipulieren. So eignen sich membranadhrente sphrische Goldnanopartikel zum Einbringen von Moleklen in Zellen. Vor allem bei Primrzellen empfiehlt die Autorin die Zugabe von Radikalfngern. Zudem nutzt sie peptidkonjugierte Goldnanopartikelagglomerate, die die Aufnahme extrazellulrer Molekle ber Endozytose untersttzen. Laserbestrahlung bewirkt effizientes intrazellulres Freisetzen der Molekle und der Agglomerate, die dabei in biokompatiblere Produkte zerteilt werden. Durch Bestrahlen goldbeschichteter Oberflchen mit Lasern entstehen Nanopartikel und Kavitationsblasen, die eukaryotische Zellen irreversibel schdigen und Biofilme manipulieren knnen.

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