Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Approaching Complex Diseases

Approaching Complex Diseases

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030328566
Condition
New
Product Description

This volume for pharmacologists, systems biologists, philosophers and historians of medicine points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Interaktion bei der Erstellung von Dienstleistungen

$64.99

Transnationalism and the German City

$54.99

Ergotherapie in der Onkologie

$44.99

Japans Nuclear Identity and Its Implications for Nuclear Abolition

$84.99

Priorisierung in der Medizin

$89.99

Pirate Stew by Neil Gaiman

$9.99

Every Other Weekend by Abigail Johnson

$16.99

Energy Storage

$69.99

The Rise of Right-Populism

$37.99

Die Neue Arbeitsgerichtsbarkeit

$59.99

Europische Kapital- und Zahlungsverkehrsfreiheit

$89.00

The Stone Wall by Beverly Lewis

$16.99

The Theory of Symmetry Actions in Quantum Mechanics

$54.99

Erfolgreich IGeLn

$54.99

return Jahrgang 2020

$99.99

N* Physics and Nonperturbative Quantum Chromodynamics

$39.99

A Brief History of Computing

$54.99

New Masters of Photoshop

$109.99

The Copyright Enforcement Enigma

$54.99

Reviews of Plasma Physics

$84.99

Die Menstruation und ihre Strungen

$59.99

Machining of Titanium Alloys

$109.99

Computational Processing of the Portuguese Language

$39.99

Healthcare Infrastructure

$84.99

Numerical Studies in Nonlinear Filtering

$39.99

Platons Gesetze

$59.99

Group Theory and Its Applications in Physics

$99.99

Analytical and Quantitative Cardiology

$39.99

Offset Reduction Techniques in High-Speed Analog-to-Digital Converters

$199.99

Impact of TRIPS in India

$54.99

Entstehung und Stoffbestand der Salzlagersttten

$79.99

Ressourcenbeschrnkte Projektplanung fr flexible Projekte

$59.99

Time in Romantic Theatre

$129.99

Praxis Grounded Theory

$39.99

Mobile Computing

$29.99

Solidarittsbrche in Europa

$39.99

Culturally Responsive Collection: Multicultural Edition Grade 3 (50 books)

$275.00

Creating Healthy and Sustainable Buildings

$59.99

Text, Speech and Dialogue

$84.99

The Relevance of Academic Work in Comparative Perspective

$84.99