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Generalisierte Markov-Modellierung

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Brand
Springer Nature
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N/A
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0
GTIN
9783658297121
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New
Product Description

Markov State Models (MSM) sind der Goldstandard zur Modellierung biomolekularer Dynamik, da sie die Identifizierung und Analyse metastabiler Zustnde ermglichen. Die robuste Perron-Cluster-Cluster-Analyse (PCCA+) ist ein verbreiteter Spectral-Clustering-Algorithmus, der fr das Clustering hochdimensionaler MSM verwendet wird. Da die PCCA+ auf reversible Prozesse beschrnkt ist, wird sie zur Generalisierten PCCA+ (G-PCCA) verallgemeinert, die geeignet ist, nichtreversible Prozesse aufzuklren. Bernhard Reuter untersucht hier mittels G-PCCA die nichtthermischen Auswirkungen von Mikrowellen auf die Proteindynamik. Dazu fhrt er molekulardynamische Nichtgleichgewichtssimulationen des Amyloid--(140)-Peptids durch und modelliert diese. Der Autor: Bernhard Reuter forscht in der Gruppe Methoden der Medizininformatik an der Eberhard-Karls-Universitt Tbingen und der Gruppe Computational Molecular Design am Zuse Institut Berlin. Ein Schwerpunkt seiner Forschung ist die Simulation und Modellierung biomolekularer Nichtgleichgewichtssysteme. Er entwickelt u.a. datenbasierte Methoden zur Modellierung biomolekularer Nichtgleichgewichtsprozesse.

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