This textbook presents an integrated view of three themes relevant to the operationalization of Management by Business Process (M-B-BP): people, process, and technology. Whereas most Business Process Management (BPM) textbooks focus on software technology issues and ontological standards for the integration of various software layers, this book focuses on the managerial perspective, managerial decisions regarding the configurations of the company's structural variables that are most favorable to the best operationalization and evolution of the M-B-BP approach. Among the structural variables of the scope of managerial choices that support the discussion are: work specialization, work grouping, the chain of command, the extent of control, the decision process, and work formalization. To support businesses managed through an organizational structure oriented by business processes, it is essential that the manager has a set of knowledge, technical skills, and professional demeanor. This text focuses on these aspects, presenting: a) the theoretical foundation, describing the central concepts of the M-B-BP approach; b) the set of necessary techniques from different areas, describing and exemplifying those skills; and c) the required behaviors of managers and employees for structuring, operation, management, and continuous improvement of the organization's business processes. For students of M-B-BP, there are examples and cases that discuss business situations and themes to aid in grasping the material while at the end of the chapters there are reflection questions as well as lists of complementary material (articles, videos, web sites). They will gain an understanding of how to create a culture of improvement. The English translation of this book from its Portuguese original manuscript was done with the help of artificial intelligence (machine translation by the service provider DeepL.com). A subsequent human revision of the content was done by the author.