The 22nd International Conference on Systems Engineering Research (CSER 2024) pushes the boundaries of systems engineering research and responds to new challenges for systems engineering. CSER was founded in 2003 by Stevens Institute of Technology and the University of Southern California. In 2024 the conference was hosted by the University of Arizona, home to the first-ever established Department of Systems Engineering. The following foundational research topics are included: Scientific Foundations of Systems Engineering Digital Engineering, Digital Twins Digital Transformation Advances in Model-Based Systems Engineering (MBSE) Value-based and Agile Systems Engineering Artificial Intelligence for Systems and Software Engineering (AI4SE) Systems and Software Engineering for Artificial Intelligence (SE4AI) Cybersecurity and System Security Engineering Uncertainty and Complexity Management Trust and Autonomous Systems Human-Systems Integration Systems of Systems Social Systems Engineering Systems Thinking Advances in requirements engineering, systems architecture, systems integration, and verification and validation. The 21st Annual Conference on Systems Engineering Research (CSER 2024) was poised to push the boundaries of systems engineering, embracing a wide array of themes from its scientific underpinnings to the forefront of digital engineering transformation and the seamless integration of artificial intelligence within systems and software engineering. Delving into cutting-edge topics such as Model-Based Systems Engineering (MBSE), cybersecurity, and the management of uncertainty and complexity, CSER 2024 tackled the varied challenges and seize the opportunities emerging in the field. The conference's commitment to blending theoretical insights with practical innovations makes it a pivotal event for the systems engineering community.