Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Molecular Analysis of DNA Rearrangements in the Immune System

Molecular Analysis of DNA Rearrangements in the Immune System

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783642501401
Condition
New
Product Description

The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro gress in somatic hypermutation.

Available Colors
Available Sizes
1 Offer Price Range: $39.99 - $39.99
BEST PRICE

Single Product Purchase

$39.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$39.99 $39.99

$39.99
See Site In stock Visit Store

Similar Products

Advances in Computational Intelligence

$89.99

Die Aktiengesellschaft

$44.99

Online-Marktforschung im Mittelstand

$59.99

The Concept of Literary Application

$54.99

Hypoxia, Metabolic Acidosis, and the Circulation

$89.99

The Political Institutions of Modern China

$54.99

Innovating in Product/Process Development

$169.99

Investigating Dynamic Relationships Among Individual Difference Variables in Learning English as a F

$119.99

Risikoanalyse

$34.99

Molecularly Targeted Therapy for Childhood Cancer

$169.00

Keyhole Approaches in Neurosurgery

$359.00

Formal Matters in Contemporary Latino Poetry

$54.99

The Work Situation of the Academic Profession in Europe: Findings of a Survey in Twelve Countries

$109.99

Multimedia Communication Technology

$199.99

Nonuniform Sampling

$229.00

Briefwechsel

$79.99

Zur Epidemiologie des Rotlaufs

$59.99

New Thinking in Complexity for the Social Sciences and Humanities

$109.99

Contemporary Topics in Cardio-Obstetrics

$129.00

Earliest Life on Earth: Habitats, Environments and Methods of Detection

$169.99

The Legacies of Ursula K. Le Guin

$69.99

Entwicklung und Erprobung eines verbesserten elektrischen Kettfadenwchtergeschirrs fr die Leinen

$59.99

Nonlinear Physics of Complex Systems

$109.00

Medical Devices and In Vitro Diagnostics

$449.99

Ecological Risk Management

$139.00

Proceedings of the 20th International Conference on Fluidized Bed Combustion

$349.00

Fortschritte der Botanik

$59.99

Life in the West (A True Book: Westward Expansion)

$5.21

Superconductivity and Electromagnetism

$139.99

Implementierung funktionaler Programmiersprachen

$59.99

Diseases of the abdomen and Pelvis

$39.99

Verallgemeinerte stochastische Prozesse

$24.99

Die Neue Soziale Frage

$59.99

Trust and Trustworthy Computing

$39.99

Miles by J. L. Esplin

$10.99

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

$169.99

Mathematisierung der Einzelwissenschaften

$49.99

Reproducible Research in Pattern Recognition

$39.99

Computational Linguistics and Intelligent Text Processing

$84.99

Researching Families and Relationships

$54.99