Copied Polyglutamine Disorders
Polyglutamine Disorders
This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntingtons disease (HD); spinalbulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
Price Comparison
| Seller | Contact Seller | List Price | On Sale | Shipping | Best Promo | Final Price | Volume Discount | Financing | Availability | Seller's Page |
|---|---|---|---|---|---|---|---|---|---|---|
|
BEST PRICE 1 Product Purchase
|
|
$109.00 | $109.00 |
|
$109.00 | See Site | In stock | Visit Store |
Reviews
Questions & Answers
Not If I Can Help It
$6.74
Radical Sociality
$54.99
Fhrung und Purpose
$54.99
Economy, Business and Uncertainty: New Ideas for a Euro-Mediterranean Industrial Policy
$169.00
The Downfall of Cartesianism 16731712
$54.99
Stochastic Linear-Quadratic Optimal Control Theory: Differential Games and Mean-Field Problems
$69.99
Magnet-Partikel-Spektrometer
$69.99
Asylum and International Law
$54.99
Gesundheitsbchlein
$59.99
Mechanics and Physics of Fracture
$169.99
Physiology of Biodegradative Microorganisms
$169.99
Atlas of Medical Parasitology
$139.99
Protein Metabolism and Homeostasis in Aging
$169.99
Assembly with Robots
$54.99
Re-Reading Tragic Africa
$119.99
Learning and Collaboration Technologies. Ubiquitous and Virtual Environments for Learning and Collab
$74.99
Management of Positive Patch Test Reactions
$54.99
Key Account Controlling in der pharmazeutischen Industrie
$49.99
Design Automation Methods and Tools for Microfluidics-Based Biochips
$169.99
Einfhrung in die PLL-Technik
$74.99
Dependent Agency in the Global Health Regime
$54.99
Slime for Dinner (Hardcover)
$9.74
Adapting to an Uncertain Climate
$109.99
Continuum Thermodynamics and Constitutive Theory
$129.99
Fernsehen digital
$29.99
Ethical Discourse in Finance
$169.99
Geldanlage und Steuern 89
$59.99
Kryptologie
$39.99
Honor Fabri and the Concept of Impetus: A Bridge between Conceptual Frameworks
$109.99
Whistleblowing zur Bekmpfung von Bilanzmanipulationen
$59.99
Computational Science and Its Applications - ICCSA 2010
$109.99
Erfolgreich abnehmen und schlank bleiben
$24.99
Genetic Counseling
$54.99
Bacteriophages
$54.99
Geographie und Fernerkundung
$59.99
Schmerz - eine Herausforderung
$9.99
Emerging Food Authentication Methodologies Using GC/MS
$199.99
Handbook of the Sociology of Morality
$219.99
The Energy-Climate Continuum
$37.99
Die Rntgenstrahlen als Hilfsmittel fr die chemische Forschung
$59.99
