Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Diuretics: Basic, Pharmacological, and Clinical Aspects

Diuretics: Basic, Pharmacological, and Clinical Aspects

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9780898388855
Condition
New
Product Description

The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.

Available Colors
Available Sizes
1 Offer Price Range: $169.00 - $169.00
BEST PRICE

Single Product Purchase

$152.10
@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$169.00 $169.00

10% OFF
This deals requires coupon Get Code Here
$152.10
See Site In stock Visit Store

Similar Products

Praxisleitfaden Online-Kurs

$39.99

Boccaccio the Philosopher

$79.99

Cell Migration

$169.99

Nuclear Energy

$84.99

Autonome Produktion

$79.99

Die Stereoskopie

$59.99

Nonlinear Approaches in Engineering Applications 2

$169.99

Dienstleistungs-Controlling

$49.99

Trade and Tax Policy, Inflation and Exchange Rates

$109.99

Top 50 Dermatology Case Studies for Primary Care

$129.99

British Intelligence and the Japanese Challenge in Asia, 19141941

$119.99

Rural Poverty in Latin America

$109.99

Scholastic Reader! Level 3: Pet Heroes

$2.99

Practical Ansible

$34.99

Modern GeometryMethods and Applications

$89.99

Stella's Starliner

$4.46

Inflationary Cosmology

$54.99

Trolls: Water-Color!: Talent Show

$8.24

Combinatoire enumerative

$44.99

Environmental Change in Iceland: Past and Present

$109.99

Churchill, Whitehall and the Soviet Union, 194045

$84.99

Guerilla Innovationsmanagement

$17.99

Computer Vision ECCV 2022

$89.00

Studies on Experimental Toxicology and Pharmacology

$169.99

Forensics in Telecommunications, Information and Multimedia

$39.99

Endokrin-aktive maligne Tumoren

$69.99

Hirschsprung's Disease and Allied Disorders

$199.99

Digitize Your Brand Name

$17.99

Sicherheitsrisiko Informationstechnik

$59.99

Transport Phenomena in Liquid Composite Molding Processes

$54.99

Handbook of Disaster Research

$249.99

The Prokaryotes

$449.99

Varieties of Marxism

$109.99

Handbook of Multivariate Experimental Psychology

$119.00

Application of Abstract Differential Equations to Some Mechanical Problems

$39.99

Understanding China's Manufacturing Industry

$109.99

Vorlesungen ber Numerische Mathematik

$59.99

OpenSHMEM and Related Technologies. OpenSHMEM in the Era of Exascale and Smart Networks

$59.99

Fourier Series in Control Theory

$39.99

Expert Systems: Uncertainty and Learning

$219.99