The Rho GTPases in Cancer

Name: The Rho GTPases in Cancer
Brand: Springer Nature
SKU: 9781441911117
Availability: InStock

The Rho GTPases in Cancer

Brand

Springer Nature

Manufacturer

N/A

Part Number

GTIN

9781441911117

Condition

New

0 Reviews

0 Questions | 0 Answers

Product Description

Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajvers laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokochs laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasas labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGSRhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeaus laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.

Available Colors

N/A

Available Sizes

N/A

1 Offer Price Range: $129.00 - $129.00

BEST PRICE

Single Product Purchase

$129.00

@ Link.springer.com BUY Now

Price Comparison

Seller	Contact Seller	List Price	On Sale	Shipping	Best Promo	Final Price	Volume Discount	Financing	Availability	Seller's Page
BEST PRICE 1 Product Purchase @ Link.springer.com Rate Seller This functionality is for registered users only. Go to Login/Register		$129.00	$129.00			$129.00		See Site	In stock	Visit Store