Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Biobetters

Biobetters

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781493925421
Condition
New
Product Description

Biobetters: Protein Engineering to Approach the Curative discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile.Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, closer to a cure as it were. For ERT,the key to optimizing clinical performance is to ensure the ERT is endowed with moietiesthat target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches.Moreover, a major failure of biotechnology based products is to gain access to theCNS,a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is avaluable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discussnovel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy.These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue- this finalchapter will explore the incentives and disincentives for developingbiobetters and consider incentives that might make their pursuit more rewarding.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$129.00
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

$129.00
See Site In stock Visit Store

Similar Products

Dog Man - Cat Kid Comic Club: On Purpose (Hardcover)

$18.74

Wilkie Collins

$54.99

Progress and Prospects in the Management of Oxyanion Polluted Aqua Systems

$109.99

Zara Hossain is Here (Hardcover)

$14.24

Ideal und Typus in der italienischen Renaissancemalerei

$49.99

IoT Development for ESP32 and ESP8266 with JavaScript

$39.99

Familienrecht fr Steuerberater

$59.99

Mastering Endo-Laparoscopic and Thoracoscopic Surgery

$59.99

Subseafloor Biosphere Linked to Hydrothermal Systems

$59.99

Smarte Kommune

$29.99

An Invitation to C*-Algebras

$64.99

Advanced Surface Coatings: a Handbook of Surface Engineering

$159.99

Advances in Neural Networks -- ISNN 2010

$84.99

Structure and Multiscale Mechanics of Carbon Nanomaterials

$109.99

Logic and the Nature of God

$84.99

Cognitive Radio Networks

$39.99

High Performance Computing

$84.99

Spanish Milan

$109.99

Die Methode der Festpunkte

$49.99

Applications of Organometallic Chemistry in the Preparation and Processing of Advanced Materials

$219.99

Molecular Targeting in Oncology

$219.99

Community Colleges and Their Students

$39.99

Air Power in the Nuclear Age, 194582

$79.99

Bone Loss and Osteoporosis

$84.99

Heteronomien des Sozialen

$39.99

Die Entstehung des modernen Konsums

$17.99

Innovation and Performance Drivers of Business Clusters

$179.99

The Co-creative Meeting

$54.99

Life in the Glory of Its Radiating Manifestations

$219.99

Politics of Hybrid Warfare

$139.99

Rookie Reader-GR Level C: All Kinds of Kids

$3.71

Metallorganische Synthesen heterocyclischer Systeme

$69.99

Children of International Migrants in Europe

$39.99

Pouchers Perfumes, Cosmetics and Soaps

$379.99

Nonlinear Systems and Controls

$109.00

Praxishandbuch Projektmanagement

$59.99

Smart Planning: Sustainability and Mobility in the Age of Change

$129.99

Formal Methods and Stochastic Models for Performance Evaluation

$54.99

Diseases of the Chest and Heart

$54.99

1x1 der chirurgischen Instrumente

$29.99