Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

New Targets in Inflammation

New Targets in Inflammation

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9789401153867
Condition
New
Product Description

For the past 100 years the mainstay of therapy for rheumatoid arthritis (RA) has been aspirin or other drugs of the non-steroid anti-inflammatory group. In 1971 Vane pro posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-2) that is encoded by a gene distinct from that of the consti tutive enzyme (COX-I) provided a new target for therapy of RA. A drug that would selectively inhibit COX-2 would hopefully produce the symptomatic benefit provided by existing NSAIDs without the gastrointestinal and renal toxicity due to the inhibition of COX-I. Drugs selective for COX-2 are now available. Experimental studies have shown them to be effective with minimal toxicity, and in clinical trials gastric and renal toxicities are less. Highly selective COX-2 inhibitors, perhaps designed with knowledge of the crystal structures of COX-I and COX-2, are also available. Other experimental studies, including those in animals lacking effective genes for COX-lor COX-2 and in experimental carcinomas, suggest there is still much to be learned of the pathophysiological functions of these enzymes. The inflammatory response is a complex reaction involving many mediators that derive from white blood cells, endothelial cells and other tissues. Preliminary data have revealed that inhibitors of the cytokines and adhesion molecules that play a crucial role in the migration of white cells to inflammatory sites may be useful in RA.

Available Colors
Available Sizes
1 Offer Price Range: $84.99 - $84.99
BEST PRICE

Single Product Purchase

$84.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$84.99 $84.99

$84.99
See Site In stock Visit Store

Similar Products

Von der Arbeitserfahrung zum Arbeitsprozewissen

$64.99

Die stereoskopische Memethode in der Praxis

$79.99

Pills for the Poorest

$84.99

Innovative Methods in Media and Communication Research

$44.99

GHG Emissions and Economic Growth

$39.99

Aktuelle Themen der Alterskardiologie

$69.99

RNA/DNA and Cancer

$169.00

Warehousing in the Global Supply Chain

$219.99

Bildungsverlufe von der Einschulung bis in den ersten Arbeitsmarkt

$54.99

Lehrbuch Grundlagen der Informatik

$84.99

Contemporary Logistics in China

$129.99

Algebraic Methods in Functional Analysis

$109.99

Rumenology

$199.99

The Medieval Fold

$39.99

Sexueller Missbrauch Mediendarstellung und Medienwirkung

$49.99

Analogrechnen

$64.99

Mobilisierung fr alle?

$59.99

Hierarchisch integrierte Produktionsplanung und -steuerung

$59.99

Distributed Computing and Artificial Intelligence, Special Sessions, 15th International Conference

$169.99

Personalarbeit - Markenzeichen eines jeden Unternehmens

$34.99

Challenges in Classical Liberalism

$179.99

Current Issues in Symbiotic Nitrogen Fixation

$169.99

Cholangiography After Orthotopic Liver Transplantation

$109.99

The Unfolding Universe

$54.99

Communicating with the World

$64.99

Eine numerische Untersuchung von Bang-Bang-Steuerungsproblemen

$39.99

Harvesting Space for a Greener Earth

$29.99

Hydrogen Molecular Biology and Medicine

$179.99

Lawyers in Business

$44.99

Assembling Nusantara

$119.99

Entwicklungsgesetze der Stadt

$59.99

Digital VLSI Systems Design

$189.00

Tumorviruses, Neoplastic Transformation and Differentiation

$109.99

Ministerialbrokratien in westlichen Demokratien

$64.99

Reporting Palestine-Israel in British Newspapers

$119.99

Theory of Elasticity and Thermal Stresses

$129.00

Building the Infrastructure for Cloud Security

$39.99

Now or Never!

$5.21

The Grand Ethiopian Renaissance Dam on the Blue Nile

$44.99

David Adler Grades 3-5

$20.50