Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Developmental Toxicology

Developmental Toxicology

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9781461597926
Condition
New
Product Description

Since the 1930s and the work of Hale and Warkany on birth defects produced by variations in dietary vitamin A, it has been recognised that the developing fetus is particularly vulnerable to adverse influences in the environment. . Studies of malformations at birth remained largely in the hands of paediatricians who, for instance, quickly established the con nection between rubella infection in early pregnancy and the birth of severely affected infants. However, it was through the tragic events of 1962, when dramatic increases in the incidence of phocomelia in newborn infants in Germany, the United Kingdom, Japan, and other countries were traced to the use of the apparently non-toxic sedative thalidomide by pregnant women, that toxicologists were brought face to face with the devastating possibility of chemically-induced developmental abnormalities. It had been shown earlier that chemotherapeutic agents could cause damage to the developing organism, but the absence of any known examples of drug-induced birth defects had produced an air of complacency which was reinforced by the lack of any specific regulatory requirements for safety evaluation in this area. The magnitude of the thalidomide tragedy, affecting some 10000 malformed children, was sufficient to cause an immediate, and some would say hasty, reaction by government drug regulatory agencies throughout the world to construct a test protocol which would detect potential teratogenic substances that might give rise to anatomical malformations.

Available Colors
Available Sizes
1 Offer Price Range: $39.99 - $39.99
BEST PRICE

Single Product Purchase

$39.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$39.99 $39.99

$39.99
See Site In stock Visit Store

Similar Products

The Reciprocal Modular Brain in Economics and Politics

$84.99

Scholar Zone Extended Learning Plus ELA & Math Grade 5

$900.00

Partizipation durch Werkstattrte

$59.99

The Peptidergic Neuron

$84.99

Great Power Competition as the New Normal of ChinaUS Relations

$39.99

Die erfolgreiche Arztpraxis

$44.99

Fractal Algorithm and Its Application in Rock Mechanics

$129.99

Japan and the Sino-Soviet Alliance, 1950-1964

$109.99

Search for a Rational Ethic

$39.99

In Command of Guardians: Executive Servant Leadership for the Community of Responders

$37.99

Kapitalbeteiligungsgesellschaften zur Finanzierung kleiner und mittlerer Unternehmungen

$59.99

Handbook of Neuropsychological Assessment

$219.99

Global Financial Crisis: The Ethical Issues

$54.99

For Nature/With Nature: New Sustainable Design Scenarios

$249.99

Pseudo-periodic Maps and Degeneration of Riemann Surfaces

$54.99

Gliomchirurgie

$229.00

Digital Mammography

$84.99

Hurdle Technologies: Combination Treatments for Food Stability, Safety and Quality

$109.99

Regular Functions of a Quaternionic Variable

$79.99

Technologie des Holzes und der Holzwerkstoffe

$89.99

Postcolonial Italy

$129.99

End User Development

$169.99

Conciliatory Democracy

$119.99

Longitudinal Methods in Youth Research

$129.99

Das Kaukasusprojekt der Alliierten vom Jahre 1940

$84.99

Mssbauer Spectroscopy Applied to Magnetism and Materials Science

$219.99

Genialitt, Depressivitt, Resilienz

$17.99

Computational Linguistics and Intelligent Text Processing

$54.99

Behavioral Synthesis and Component Reuse with VHDL

$169.99

Interstellar Propagation of Electromagnetic Signals

$54.99

Handbuch Medienerziehung im Kindergarten

$64.99

On the Use of Stochastic Processes in Modeling Reliability Problems

$54.99

Handbook of FPGA Design Security

$84.99

Grenzen der Medizin

$44.99

Lassalles Briefwechsel mit Grfin Sophie von Hatfeldt

$59.99

Pattern Recognition

$109.99

Transplantation

$44.99

Diseases of the Inner Ear

$119.00

Domain Modeling-Based Software Engineering

$219.99

Chirality

$39.99