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Untersuchung des tumorrelevanten Proteins Survivin

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Brand
Springer Nature
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N/A
Part Number
0
GTIN
9783658271916
Condition
New
Product Description

Survivin ist in nahezu allen malignen Tumorerkrankungen berexprimiert und aufgrund seiner dualen Rolle als Apoptose-Inhibitor und Zellzyklus-Regulator an zwei entscheidenden Prozessen der Onkogenese beteiligt. Fr die Ausbung beider biologischer Funktionen ist die Interaktion von seinem Kernexportsignal mit dem Exportrezeptor Crm1 essentiell, weshalb die gezielte Inhibition dieser Interaktion einen guten Angriffspunkt fr die Krebstherapie darstellt. Lisa Oelschlger analysiert die Effekte supramolekularer Liganden auf die Funktion von Survivin, die mit ihrer hohen Affinitt gegenber oberflchenexponierten Lysin- und Arginin-Seitenketten einen vielversprechenden neuen Ansatz zur gezielten Inhibition der Survivin-Crm1-Interaktion darstellen.

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