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Auswirkungen renal-tubulrer Aktivierung von Hypoxie-induzierbaren Faktoren auf die Erythropoietin-P

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Brand
Springer Nature
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N/A
Part Number
0
GTIN
9783658173623
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New
Product Description

Zur Untersuchung des Einflusses von tubulrem HIF auf die renale EPO-Produktion generierte Navid Farsijani ein genetisches Mausmodell, in dem durch tubulre Vhl-Ablation, tubulre Epithelzellen HIF berexprimieren. Die tubulre Vhl-Ablation fhrte zu einer prompten Suppression der renalen EPO-Produktion. Anhand weitere konditioneller Mausmodelle zeigt der Autor, dass die Entwicklung der Anmie von HIF-abhngig ist, proximale Tubuluszellen fr die Regulation von EPO im Nephron verantwortlich sind und die tubulre Vhl-Ablation mit einer Reduktion der mitochondrialen Masse sowie einer Erhhung des kortikalen Gewebssauerstoffpartialdruckes (PtO2) einhergeht. Dies spricht fr eine multi-zellulre Regulation der renalen EPO-Synthese, in der eine Homostase zwischen tubulren Epithelzellen und REPC fr eine adquate EPO-Produktion der Niere notwendig ist. Zudem knnte der EPO-suppressive Effekt von tubulrem HIF einen pathophysiologischen Faktor in der Entstehung von renalen Anmien darstellen.

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