Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

Progranulin and Central Nervous System Disorders

Progranulin and Central Nervous System Disorders

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9789811361852
Condition
New
Product Description

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches formultiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Available Colors
Available Sizes
1 Offer Price Range: $84.99 - $84.99
BEST PRICE

Single Product Purchase

$84.99
@ Link.springer.com     BUY Now

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$84.99 $84.99

$84.99
See Site In stock Visit Store

Similar Products

From Opinion Mining to Financial Argument Mining

$37.99

Revisiting Gender Inequality

$39.99

Betriebswirtschaftslehre der Industrie

$59.99

Pedagogic Criticism

$79.99

Justice and Foreign Rule

$54.99

Nature-Based Solutions for Flood Mitigation

$229.00

Die dezentrale Hauptversammlung

$59.99

Die Geltung von Rechtsnormen

$69.99

Pentecostalism and Prosperity

$139.99

Advances in Production Management Systems. Production Management Systems for Volatile, Uncertain, Co

$109.99

Project Management in Logistics and Supply Chain Management

$109.99

Mathematical Modeling for the Life Sciences

$54.99

The Middle East in the New World Order

$89.00

Zur Technik der Kropfoperation

$59.99

Management of Technology and Innovation in Japan

$54.99

Last of the Black Titans

$39.99

Best Friends in the Universe (Hardcover)

$14.24

Design Thinking Research

$169.99

Transitions to Adulthood in the Middle East and North Africa

$54.99

Die Kulturkonzeption

$49.99

Agile Swift

$32.99

Advances in Computational Mechanics and Applications

$189.00

Electrochemically Engineered Nanoporous Materials

$109.99

Global Citizenship, Ecomedia and English Language Education

$159.99

Sechspunktige Kreisfhrungen durch das Gelenkviereck

$59.99

Efficient Checking of Polynomials and Proofs and the Hardness of Approximation Problems

$39.99

Optimistic Library Grade 5

$295.00

The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses

$74.99

Advances in Human Factors in Cybersecurity

$119.00

Dynamic Decision Theory

$39.99

Tools and Methods for Pollution Prevention

$109.99

An Artificial Intelligence Approach to Test Generation

$84.99

Internationalisation of European ICT Activities

$109.99

Self-powered SoC Platform for Analysis and Prediction of Cardiac Arrhythmias

$109.99

Evolutionary Web Development

$63.95

Biosaline Agriculture and High Salinity Tolerance

$219.99

Acoustic Signal Processing for Ocean Exploration

$259.00

Die Projektdarsteller: Karriere als Inszenierung

$39.99

Business Ethics and Leadership from an Eastern European, Transdisciplinary Context

$109.99

Airy and Other Analytical Waves for Beginners

$29.99