This book presents descriptions of interventions, results of empirical research, and theoretical contributions developed by Latine/x psychologists based on affirmative approaches aimed at promoting acceptance and understanding of LGBTIQ+ people. Contributions in this volume bring together the work of Latine/x scholars, practitioners, and activists across five Latin American countries or territories (Argentina, Chile, Colombia, Mexico, and Puerto Rico) and in the United States, in an effort to provide multicultural perspectives to LGBTIQ+ affirmative psychological interventions that highlight local, regional and national particularities. Chapters in this volume go beyond contributions made by applied psychology fields (e.g., clinical and counselling psychology), where affirmative orientations are predominantly located, and include contributions from other fields of psychological research such as social and community psychology. The book is divided in two parts. Chapters in the first part focus on the experiences of trans and gender non-conforming people, with emphasis on contemporary systemic issues that affect gender identity among Latine/x communities and those who do not conform to hegemonic narratives about gender. Chapters in the second part focus on sexual identity among Latine/x LGBTIQ+ people and their families and communities. Contributions in this part present discussions about sexual orientation (grouped in LG/LGB identities), sex and gender dissidence, and the inclusion of intersex. LGBTQ+ Affirmative Psychological Interventions: A Latine/x Perspective will be of interest to both researchers and practitioners in different fields of psychology such as clinical, counselling, social, and community psychology interested in a multicultural perspective to understand and develop LGBTQ+ affirmative actions to fight against the repathologization of individuals, groups, families and diverse communities.