Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and supports neurotransmitter receptor affinity. SAM-e supports healthy joints both by helping increase the number of articular chondrocytes and by stimulating the synthesis of sulfated proteoglycans therein.*SAM-e also protects synovial cells and helps block enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.* SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.''Dietary ConsiderationsWheat FreeDairy/ Milk FreeGluten FreeSoy FreeYeast FreeSugar FreePreservative FreeSalt FreeCorn FreeFree of Artificial Colors/Flavors''Serving Size:2 Tablet''Servings Per Container:30 '''' Amount Per Serving B3 (niacinamide) 30''mg ''B6 (pyridoxine HCI) 2''mg ''Folic Acid 400''mcg ''B12 (cyanocobalamin) 20''mcg ''SAM-e (tosylate disulfate) 400''mg ''Choline (bitartrate) 50''mg ''''Other ingredients: calcium sulfate, vegetable stearine, silica, vegetable coating ''''''''Suggested use for adults: Two to four tablets daily, preferably morning and evening, or as directed by your health care practitioner.*Enterically coated tablets''This product container no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring. This product is intended for professional use and is manufactured under strict quality control to ensue the optimum in purity, potency and reliability.''Keep in a cool, dry place, tightly capped. ''''.