Jarrow Formulas SAMe 400 provides a full 400 SAMe (net yield) from 800 of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.Contains More of the Active S,S FormFound in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.SAMe has been clinically shown to have the following benefits:Joint StrengthSAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.Brain MetabolismSAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).LiverSAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification.Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.Full Potency 400 SAMe (net yield) is derived from 800 of SAMe tosylate disulfate.For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.Dietary ConsiderationsWheat FreeDairy/ Milk FreeGluten FreeVegetarianSoy FreeVeganEgg FreeShellfish FreeFish FreeTree Nut FreePeanut FreeServing Size:1 TabletServings Per Container:60Amount Per ServingS-Adenosyl Methionine (from 400 of SAM-e tosylate disulfate) mgOther Ingredients:Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate, enteric coating modified cellulose, magnesium silicate, triethyl citrate, riboflavinSuggested UseTake 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.Suitable for vegetarians/vegans. No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.WARNINGIndividuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended dose. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.Jarrow Formulas SAM-e is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.Contains More of the Active S,S Form Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.