Copied The Role of Toll-Like Receptor Infectious and Non Infectious Inflammation
The Role of Toll-Like Receptor Infectious and Non Infectious Inflammation
TLR4 is one of the most important innate immunity receptors, its function mainly consisting the activation of inflammatory pathways response to stimulation by Pathogen-Associated Molecular Patterns (PAMPs) and Damage Associated Molecular Pattern molecules (DAMPs). This volume critically reviews the different types of TLR4 activators and inhibitors, discusses the role of molecular aggregates agonism/antagonism as well as the pivotal role of the CD14 receptor the modulation of TLR4 signal and the molecular details and actors of the intracellular cascade. The book presents the role of TLR4 several pathologies, such as sepsis and septic shock caused by receptor activation by gram-negative bacterial lipopolysaccharide (LPS), neurodegenerative and neurological diseases such as Parkinson and Alzheimers diseases, and Amyotrophic Lateral Sclerosis (ALS). It reviews the role of TLR4 neural stem cell-mediated neurogenesis andneuroinflammation and Human Induced Pluripotent Stem Cells and Cerebral Organoids and discusses the emerging role of micro-RNA (miRNA) regulation by TLR4.
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