Clinically-researched botanicals to support immune, cellular and tissue health Perluxan is a clinically studied extract of hops specifically developed to promote joint health. In a randomized, double-blind placebo-controlled trial of 36 subjects, the benefits of Perluxan on joint comfort reached statistical significance within two hours of the first dose and were sustained over the 14-day period. Perluxan is free of sleep-inducing and phytoestrogenic compounds typically associated with hops extracts. The alpha and iso-alpha acids in Perluxan maintain healthy NF-kappa B-associated expression of COX-2 and cytokines such as IL-6 and TNFa in connective tissue. Curcumin complements Perluxan through its extensively characterized effects on cytokine-mediated signal transduction, matrix metalloproteinase (MMP) expression and multiple components of the arachidonic acid cascade. Curcumin C3 Complex is the subject of extensive ongoing clinical investigations at numerous hospitals and universities. Ginger promotes joint health through maintaining healthy cytokine signaling in cartilage and the synovium. 5LOXIN Boswellia serrata extract provides the highly bioactive triterpenoid AKBA, which supports connective tissue structural composition and comfort through supporting healthy immune responses, 5-lipoxygenase activity, and synovial matrix metalloproteinase 3 (MMP-3) levels. In a 3-month double-blind, placebo-controlled study of 75 subjects, significant functional support and comfort scores were evident as early as day 7. Supports immune, cellular and tissue health Made with hypoallergenic, vegan ingredients Dietary Considerations Gluten Free Non-GMO Serving Size: 2 Capsule Servings Per Container: 30 Amount Per Serving Perluxan hops (Humulus lupulus) extract (cone) 500 mg curcumin Curcumin C3 Complex turmeric (Curcuma longa) extract (root) (standardized to contain 95% curcuminoids)C3 Complex turmeric (curcuma longa) extract (root)(standardized to contain 95% curcuminoids) 200 mg Ginger (Zingiber officinale) extract (root) (standardized to contain 5% gingerols) 200 mg 5-LOXIN Boswellia serrata extract Indian frankincense (Boswellia serrata) extract (gum resin) (standardized to contain 30% 3-acetyl-11-keto-beta-boswellic acid (AKBA)) 100 mg Other Ingredients: vegetarian capsule (cellulose, water), maltodextrin, silica, ascorbyl palmitate As a dietary supplement, take 2 capsules daily, with a meal. Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children. Use only if safety seal is intact. Store in a cool, dry place.