Fem-Dophilus contains two patented and clinically documented probiotic strains, Lactobacillus rhamnosus, GR-1 and Lactobacillus reuteri, RC-14, discovered and developed by Dr. Gregor Reid and Dr. Andrew Bruce at Urex Biotech. Over 25 years of research supports the oral use of GR-1 and RC-14 to colonize and promote healthy vaginal and urinary tract health. A special manufacturing process protects the probiotic strains in Fem-Dophilus from stomach acid and enhances probiotic bacterial survival to the lower intestine. Fem-Dophilus does not require refrigeration and can be stored at room temperature. Refrigeration will, however, extend the shelf life. Avoid temperatures above 77F (25C). GR-1/RC-14 and VAGINAL FLORA (also called microbiota) In one of the randomized clinical trials, 75% of women in the GR-1/RC-14 probiotic group experienced significant improvement in vaginal flora composition, while only 34% of women in the placebo (non-probiotic) group experienced similar improvement.Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Vegetarian Soy Free Vegan Egg Free Shellfish Free Fish Free Tree Nut Free Peanut FreeServing Size:1 Vegetable CapsuleServings Per Container:30Amount Per Serving Total Probiotic Blend 1 Billion viable cellsComposed of the following strains: Lactobacillus rhamnosus, GR-1 Lactobacillus reuteri, RC-14Other Ingredients: Maltodextrin (non-GMO source), cellulose, magnesium stearate (vegetable source), Capsule consists of hydroxypropylmethylcellulose, titanium dioxide (for coloring) For maintenance, take 1 capsule orally per day, preferably with a meal and a glass of water, and increase to 2 capsules per day as needed or take as directed by your qualified healthcare professional. If your healthcare professional recommends taking this product in conjunction with antibiotics, take at least 1-2 hours after taking the medication. Fem-Dophilus does not require refrigeration and can be stored at room temperature. Refrigeration will, however, extend the shelf life. Avoid temperatures above 77F (25C). Keep out of the reach of children.